黑龙江医学
黑龍江醫學
흑룡강의학
HEILONGJIANG MEDICAL JOURNAL
2014年
7期
756-757,758
,共3页
帕金森病%药源性异动症%病因分析
帕金森病%藥源性異動癥%病因分析
파금삼병%약원성이동증%병인분석
Parkinson′s disease%Drug induced dyskinesias%Etiological analysis
目的：分析引起帕金森病药源性异动症的相关因素。方法对我院2008-01～2013-12间收治的242例帕金森病患者资料进行分析，其中发生药源性异动症42例，对异动症患者的临床表现、药物使用史、症状出现时间进行分析。结果帕金森病药源性异动症的发生率为17.36％（42/242），其中剂峰异动22例，占52.38％（22/42）；肌张力障碍18例，占42.86％（18/42）；双相异动2例，占4.76％（2/42）。男性发病率略高于女性，但差异无显著性（ P＞0.05）。疗程＞5年、药物剂量≥350 mg/d、发病年龄＜60岁是发生药源性异动症的主要因素，以上因素具有代表性（ P＜0.05）。病情严重程度与服药剂量和服药时间呈正相关，与年龄呈负相关。结论帕金森病药源性异动症是左旋多巴治疗后常见的并发症，药物用量大、服用时间长是引发该病的主要因素。因此，在治疗帕金森病时，症状改善后应注意控制用药剂量或使用其他药物替代部分用量，以降低发病率。
目的：分析引起帕金森病藥源性異動癥的相關因素。方法對我院2008-01～2013-12間收治的242例帕金森病患者資料進行分析，其中髮生藥源性異動癥42例，對異動癥患者的臨床錶現、藥物使用史、癥狀齣現時間進行分析。結果帕金森病藥源性異動癥的髮生率為17.36％（42/242），其中劑峰異動22例，佔52.38％（22/42）；肌張力障礙18例，佔42.86％（18/42）；雙相異動2例，佔4.76％（2/42）。男性髮病率略高于女性，但差異無顯著性（ P＞0.05）。療程＞5年、藥物劑量≥350 mg/d、髮病年齡＜60歲是髮生藥源性異動癥的主要因素，以上因素具有代錶性（ P＜0.05）。病情嚴重程度與服藥劑量和服藥時間呈正相關，與年齡呈負相關。結論帕金森病藥源性異動癥是左鏇多巴治療後常見的併髮癥，藥物用量大、服用時間長是引髮該病的主要因素。因此，在治療帕金森病時，癥狀改善後應註意控製用藥劑量或使用其他藥物替代部分用量，以降低髮病率。
목적：분석인기파금삼병약원성이동증적상관인소。방법대아원2008-01～2013-12간수치적242례파금삼병환자자료진행분석，기중발생약원성이동증42례，대이동증환자적림상표현、약물사용사、증상출현시간진행분석。결과파금삼병약원성이동증적발생솔위17.36％（42/242），기중제봉이동22례，점52.38％（22/42）；기장력장애18례，점42.86％（18/42）；쌍상이동2례，점4.76％（2/42）。남성발병솔략고우녀성，단차이무현저성（ P＞0.05）。료정＞5년、약물제량≥350 mg/d、발병년령＜60세시발생약원성이동증적주요인소，이상인소구유대표성（ P＜0.05）。병정엄중정도여복약제량화복약시간정정상관，여년령정부상관。결론파금삼병약원성이동증시좌선다파치료후상견적병발증，약물용량대、복용시간장시인발해병적주요인소。인차，재치료파금삼병시，증상개선후응주의공제용약제량혹사용기타약물체대부분용량，이강저발병솔。
Objective To analyze the factors related to drug -induced dyskinesias in Parkinson′s disease.Methods In the hospital , during January, 2008 and December, 2013, 242 patients with Parkinson′s disease were analyzed, and 42 cases of drug-induced dyskinesias occurred among them.The clinical manifestation of the patients with dyskinesia , drug use history and symptom were analyzed.Results The drug induced dyskinesia in Parkinson′s disease incidence rate was 17.36% ( 42/242 ) , including 22 cases of peak dose changes , accounting for 52.38%(22/42);dystonia in 18 cases, accounting for 42.86%(18/42);dual phase changes in 2 cases, accounting for 4.76%(2/42).The incidence of male was higher than female , but the difference was not significant (P>0.05).Treatment was more than 5 years,the drug dose≥350 mg/d, onset age <60 years old were the main factors of drug induced dyskinesias , with more representa-tive factors ( P <0.05 ).The severity had positive factor on medical dose and dosing time , and had negative correlation with age.Conclusion Drug induced dyskinesia in Parkinson′s disease is a common complication after levodopa treatment.Drug dosage and tak-ing a long time are the main factors causing the disease , therefore, in the treatment of Parkinson′s disease, after symptoms improvement, care should be taken to control the dosage or the use of other drugs to replace part of consumption , in order to reduce the incidence.
