CAJ | 학술논문

活化白细胞黏附分子（ ALCAM）是免疫球蛋白基因超家族成员，主要表达在白细胞和胸腺上皮细胞，其通过异嗜性黏附形式（ ALCAM-CD6）和同嗜性黏附形式（ ALCAM-ALCAM）介导细胞间黏附。研究表明，ALCAM参与多种肿瘤的发生发展，与恶性黑色素瘤、结肠癌、乳腺癌和神经胶质瘤等侵袭与转移密切相关。
활화백세포점부분자（ ALCAM）시면역구단백기인초가족성원，주요표체재백세포화흉선상피세포，기통과이기성점부형식（ ALCAM-CD6）화동기성점부형식（ ALCAM-ALCAM）개도세포간점부。연구표명，ALCAM삼여다충종류적발생발전，여악성흑색소류、결장암、유선암화신경효질류등침습여전이밀절상관。
Activated leukocyte cell adhesion molecule ( ALCAM) is a member of immunoglobulin gene super family.It is mainly ex-pressed on leucocytes and thymic epithelial cells.ALCAM mediates cell -cell interactions by both heterophilic ( ALCAM-CD6 ) and ho-mophilic(ALCAM-ALCAM).Studies show that ALCAM plays a role on tumorigenesis and progression.ALCAM expression is closely correlated with invasion and metastasis of several human tumors , including malignant melanoma ,colon carcinoma , breast cancer and glio-blastoma.