国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2014年
7期
545-548
,共4页
岳丽娟%侯新丽%薛辉%薛玲%高翔%沈勇%袁亮%张晶晶%朱宏财
嶽麗娟%侯新麗%薛輝%薛玲%高翔%瀋勇%袁亮%張晶晶%硃宏財
악려연%후신려%설휘%설령%고상%침용%원량%장정정%주굉재
顺铂%乳腺肿瘤%治疗应用
順鉑%乳腺腫瘤%治療應用
순박%유선종류%치료응용
Cisplatin%Breastneoplasms%Therapeuticuses
目的:研究培美曲塞联合顺铂方案治疗晚期乳腺癌的近期临床疗效和不良反应。方法采用信封法随机分为治疗组和对照组。治疗组18例晚期乳腺癌用培美曲塞联合顺铂方案治疗,对照组23例晚期乳腺癌用吉西他滨联合顺铂治疗,21 d为一个周期。按世界卫生组织(WHO)关于实体瘤治疗疗效评价标准和化疗毒性评价标准(CTCAE),判断近期疗效和药物的不良反应。结果治疗组的肿瘤控制率为83.3%(15/18),对照组为78.3%(18/23),两组差异无统计学意义(χ2=0.00094,P>0.05);而治疗组和对照组的不良反应比较,两组差异均有统计学意义(骨髓抑制χ2=9.23;疲乏χ2=4.96;恶心、呕吐χ2=4.98;腹泻χ2=4.45;皮疹χ2=5.03,P均<0.05)。结论培美曲塞联合顺铂方案对晚期乳腺癌患者具有很好的疗效,且不良反应低。
目的:研究培美麯塞聯閤順鉑方案治療晚期乳腺癌的近期臨床療效和不良反應。方法採用信封法隨機分為治療組和對照組。治療組18例晚期乳腺癌用培美麯塞聯閤順鉑方案治療,對照組23例晚期乳腺癌用吉西他濱聯閤順鉑治療,21 d為一箇週期。按世界衛生組織(WHO)關于實體瘤治療療效評價標準和化療毒性評價標準(CTCAE),判斷近期療效和藥物的不良反應。結果治療組的腫瘤控製率為83.3%(15/18),對照組為78.3%(18/23),兩組差異無統計學意義(χ2=0.00094,P>0.05);而治療組和對照組的不良反應比較,兩組差異均有統計學意義(骨髓抑製χ2=9.23;疲乏χ2=4.96;噁心、嘔吐χ2=4.98;腹瀉χ2=4.45;皮疹χ2=5.03,P均<0.05)。結論培美麯塞聯閤順鉑方案對晚期乳腺癌患者具有很好的療效,且不良反應低。
목적:연구배미곡새연합순박방안치료만기유선암적근기림상료효화불량반응。방법채용신봉법수궤분위치료조화대조조。치료조18례만기유선암용배미곡새연합순박방안치료,대조조23례만기유선암용길서타빈연합순박치료,21 d위일개주기。안세계위생조직(WHO)관우실체류치료료효평개표준화화료독성평개표준(CTCAE),판단근기료효화약물적불량반응。결과치료조적종류공제솔위83.3%(15/18),대조조위78.3%(18/23),량조차이무통계학의의(χ2=0.00094,P>0.05);이치료조화대조조적불량반응비교,량조차이균유통계학의의(골수억제χ2=9.23;피핍χ2=4.96;악심、구토χ2=4.98;복사χ2=4.45;피진χ2=5.03,P균<0.05)。결론배미곡새연합순박방안대만기유선암환자구유흔호적료효,차불량반응저。
Objective Tostudyrecentclinicalefficacyandadversereactionsofpemetrexedincombi-nationwithcisplatininthetreatmentofadvancedbreastcancer.Methods Usingenvelopesandrandomlythe patients were dividing into treatment group and control group.The treatment group with 1 8 cases of advanced breast cancer were treated with pemetrexed and cisplatin while in the control group ,23 cases advanced breast cancer patients were treated with gemcitabine and cisplatin with 21 days as a cycle.The efficacy and adverse re-actions were determined according to the WHO on Response Evaluation Criteria in Solid Tumors therapy and chemotherapytoxicityevaluationcriteria.Results Tumorcontrolrateinthetreatmentgroupwas83.3%(1 5/1 8),while in the control group was 78.3%(1 8/23 ),and the difference was not statistically significant (χ2 =0.000 94,P>0.05);while the adverse reactions differenced between the treatment group and the con-trol group were statistically significant(bone marrow suppression χ2 =9.23;fatigue χ2 =4.96;nausea and vomi-tingχ2=4.98;diarrheaχ2=4.45;skinrashχ2=5.03,P<0.05).Conclusion Pemetrexedcombinedwith cisplatin in patients with advanced breast cancer has a good effect,and the adverse reaction is low.