CAJ | 학술논문

核因子-κB（NF-κB）是哺乳动物真核细胞中重要的转录因子，在机体免疫、炎症以及肿瘤的发生发展、浸润转移、肿瘤细胞凋亡方面起着重要作用。近年来研究发现，NF-κB在肿瘤中高表达与肿瘤耐放射治疗及预后差密切相关，NF-κB可作为评价放疗疗效及预后的指标。针对NF-κB激活的通路，可以从不同的方面寻找药物抑制NF-κB的激活，提高放疗疗效。
핵인자-κB（NF-κB）시포유동물진핵세포중중요적전록인자，재궤체면역、염증이급종류적발생발전、침윤전이、종류세포조망방면기착중요작용。근년래연구발현，NF-κB재종류중고표체여종류내방사치료급예후차밀절상관，NF-κB가작위평개방료료효급예후적지표。침대NF-κB격활적통로，가이종불동적방면심조약물억제NF-κB적격활，제고방료료효。
NuclearfactorκB(NF-κB)isanimportanttranscriptionfactorinmammaliancells.Asa multifunctional factor,NF-κB is involved in a variety of physiological and pathological processes such as immu-nity and inflammation .At the molecular and cellular level,NF-κB regulates initiation and progression of neo-plasms.NF-κB also plays an important role in cell proliferation and apoptosis of neoplasms.Radiotherapy is one of the most important methods in tumor treatment .In recent years,a number of studies discovered that NF-κB is critical in the development of resistance of tumor cells to radiotherapy,which results in poor progno-sis.We can use NF-κB as a biomarker in predicting outcomes of anticancer treatment or as prognostic indicators in patients who are with tumors.So we can find different potential inhibitors aimed at NF-κB and its signal pathway in order to improve the efficacy of radiotherapy.In the present study,the correlation of NF-κB mole-cules with radiotherapy of neoplasms is reviewed.