CAJ | 학술논문

着丝粒蛋白F（CENP-F）是细胞周期依赖性的着丝粒蛋白，其表达和定位具有严格的细胞周期性。CENP-F在肿瘤发生中起重要作用。CENP-F在多种肿瘤中表达上调，是重要的细胞增殖标志物，研究显示与肿瘤的发生、发展、侵袭、复发与预后等相关，是一个有价值的肿瘤预后指标和潜在治疗靶点。
착사립단백F（CENP-F）시세포주기의뢰성적착사립단백，기표체화정위구유엄격적세포주기성。CENP-F재종류발생중기중요작용。CENP-F재다충종류중표체상조，시중요적세포증식표지물，연구현시여종류적발생、발전、침습、복발여예후등상관，시일개유개치적종류예후지표화잠재치료파점。
CENP-Fisacell-cycledependentkinetochoreprotein,whoseexpressionandlocalization patterns are regulated in a cell cycle-dependent manner.CENP-F plays an important role in the development and progress of malignant tumor.The expression of CENP-F is up-regulated in many tumors.It serves as an important marker in cell proliferation.Studies have demonstrated that CENP-F is involved in tumor genesis, progress,invasiveness,relapse and prognosis.CENP-F might be a valuable prognostic marker and potential therapy target in cancer treatment.