CAJ | 학술논문

表观遗传调控在基因表达、DNA复制、修复和重组等重要过程中起着关键作用，表观遗传调控异常会引发多种疾病尤其是癌症。SNF5是SWI-SNF染色体重塑复合物的核心成分之一，具有强效抑癌作用。果蝇zeste基因增强子同源物2（EZH2）是目前与肿瘤关联密切且复杂的组蛋白甲基化酶，具有促癌功能。已有研究报道了表观遗传调控因子SNF5和EZH2在不同肿瘤发生发展中的作用及二者之间的相互关系。
표관유전조공재기인표체、DNA복제、수복화중조등중요과정중기착관건작용，표관유전조공이상회인발다충질병우기시암증。SNF5시SWI-SNF염색체중소복합물적핵심성분지일，구유강효억암작용。과승zeste기인증강자동원물2（EZH2）시목전여종류관련밀절차복잡적조단백갑기화매，구유촉암공능。이유연구보도료표관유전조공인자SNF5화EZH2재불동종류발생발전중적작용급이자지간적상호관계。
EpigeneticsreferstoheritablealterationsingeneexpressionthatdonotinvolvetheDNA coding sequence itself.Epigenetic regulation plays an important role in gene expression,DNA replication,rep-aration and reconstitution. Thus, the abnormity of epigenetic regulation may lead to different diseases, especially cancer.SNF5 ,which can suppress tumor significantly,is one of the core components of SWI/SNF chromosome remodeling complexes.EZH2,a histone methyltransferase,is closely and complicatedly related to cancer and has significant effect on tumorigenesis.There are many studies reporting the effects of epigenetic regulation factors-SNF5 and EZH2 on different tumors as well as the interrelation at present.In the present paper,the advances in the research on these two epigenetic regulation factors in the carcinogenesis are reviewed.