CAJ | 학술논문

Kruppel样因子9（KLF9）是参与基因转录调控的锌指蛋白之一，广泛参与了细胞的增殖、分化以及组织器官的分化发育等过程。KLF9在多种肿瘤组织及肿瘤细胞中低表达，对肿瘤细胞的增殖及凋亡发挥重要作用。KLF9可以通过多种信号途径以及与细胞内不同蛋白的相互作用，影响肿瘤细胞的增殖及凋亡，影响肿瘤的形成和发展，在内分泌相关肿瘤方面KLF9的作用尤为明显。
Kruppel양인자9（KLF9）시삼여기인전록조공적자지단백지일，엄범삼여료세포적증식、분화이급조직기관적분화발육등과정。KLF9재다충종류조직급종류세포중저표체，대종류세포적증식급조망발휘중요작용。KLF9가이통과다충신호도경이급여세포내불동단백적상호작용，영향종류세포적증식급조망，영향종류적형성화발전，재내분비상관종류방면KLF9적작용우위명현。
KLF9(Kruppel-likefactor9)isthetranscriptionfactorthatcanbindGC-richsitesthrough three C2H2-type zinc fingers and can regulate diverse biological processes,including cell proliferation,apopto-sis and the development of the organ.KLF9 is downregulated in some tumor specimens and tumorous cell lines relative to the normal samples and cell lines and plays an important role in the growth of cancer cells.Similar with the other KLF numbers,KLF9 could affect the development of tumors,especially for the endocrine-related cancers through multiple signaling pathways and interventions with other proteins.