CAJ | 학술논문

目的：分析类风湿因子（RF）、抗环瓜氨酸肽抗体（CCP）、抗角蛋白抗体（AKA）在RA诊断中的意义。方法选取RA患者356例，其他自身免疫性疾病150例，进行相关实验指标的测定，并对结果进行统计学分析。结果 RF、抗CCP抗体、AKA在RA患者中阳性率、灵敏度及特异度均较高，抗CCP抗体阳性组肿胀关节数、压痛关节数、C反应蛋白（CRP）、28个关节疾病活动度评分（DAS28）、RF高于抗CCP抗体阴性组，2组比较P＜0．05，差异有统计学意义。结论联合检测RF、抗CCP抗体、AKA有助于RA的诊断和鉴别诊断，且抗CCP抗体和RA疾病活动度有关。
목적：분석류풍습인자（RF）、항배과안산태항체（CCP）、항각단백항체（AKA）재RA진단중적의의。방법선취RA환자356례，기타자신면역성질병150례，진행상관실험지표적측정，병대결과진행통계학분석。결과 RF、항CCP항체、AKA재RA환자중양성솔、령민도급특이도균교고，항CCP항체양성조종창관절수、압통관절수、C반응단백（CRP）、28개관절질병활동도평분（DAS28）、RF고우항CCP항체음성조，2조비교P＜0．05，차이유통계학의의。결론연합검측RF、항CCP항체、AKA유조우RA적진단화감별진단，차항CCP항체화RA질병활동도유관。
Objective To explore the clinical significance of rheumatoid factor (RF), anti-cyclic citrullinated peptide antibodies (anti-CCPs) and anti-keratin antibody (AKA) in patients with rheumatoid arthritis (RA). Methods We analyzed the three antibodies in 356 patients with RA and 150 with other autoimmune diseases, which allowed statistic analysis. Results The positivity, sensitivity and specificity of the RF, anti-CCPs and AKA were significantly higher in RF than in other autoimmune diseases (all P<0.05). The swollen joint count (SJC), tenderness joint count (TJC), CRP, DAS28 and the titer of RF were higher in the anti-CCPs positive group than in anti-CCPs negative group (all P<0.05). Conclusion The combination of RF, anti-cyclic citrullinated peptide and AKA may have diagnostic val-ue in early-stage RA. The level of anti-CCPs is associated with the disease activity of RA.