中国药物与临床
中國藥物與臨床
중국약물여림상
CHINESE REMEDIES & CLINICS
2014年
8期
1012-1014
,共3页
吕倩%罗静%高惠英%李小峰%温鸿雁%张婷婷%张思雨
呂倩%囉靜%高惠英%李小峰%溫鴻雁%張婷婷%張思雨
려천%라정%고혜영%리소봉%온홍안%장정정%장사우
肺疾病,间质性%诊断%特发性炎性肌病%血清表面活性蛋白
肺疾病,間質性%診斷%特髮性炎性肌病%血清錶麵活性蛋白
폐질병,간질성%진단%특발성염성기병%혈청표면활성단백
Lung diseases,interstitial%Diagnosis%Idiopathic inflammatory myopathy%Serum surfactant pro-tein
目的：通过对特发性炎性肌病（IIM）合并间质性肺病（ILD）患者的血清表面活性蛋白A（SP-A）和D（SP-D）的研究，探讨其与IIM合并ILD的相关性。方法采用双抗体夹心酶联免疫吸附试验检测SP-A和SP-D，比较单纯IIM组、IIM-ILD组、对照组血清样本SP-A和SP-D水平的差异。分析IIM-ILD组SP-A和SP-D与年龄、肌力、红细胞沉降率（ESR）、C反应蛋白（CRP）及肌酶之间的相关性。结果①IIM-ILD组患者血清SP-A和SP-D水平高于单纯IIM组以及对照组（P＜0．05）。单纯IIM组和健康对照组患者血清SP-A和SP-D水平比较差异无统计学意义（P＞0．05）。血清SP-A、SP-D之间具有较高的正相关性。②IIM-ILD患者血清SP-A、SP-D水平与年龄、肌力、ESR、C反应蛋白及肌酶无相关性。结论 SP-A和SP-D与IIM合并ILD具有相关性，可作为IIM合并ILD的血清学标志，在早期诊断IIM合并ILD方面有一定价值。
目的：通過對特髮性炎性肌病（IIM）閤併間質性肺病（ILD）患者的血清錶麵活性蛋白A（SP-A）和D（SP-D）的研究，探討其與IIM閤併ILD的相關性。方法採用雙抗體夾心酶聯免疫吸附試驗檢測SP-A和SP-D，比較單純IIM組、IIM-ILD組、對照組血清樣本SP-A和SP-D水平的差異。分析IIM-ILD組SP-A和SP-D與年齡、肌力、紅細胞沉降率（ESR）、C反應蛋白（CRP）及肌酶之間的相關性。結果①IIM-ILD組患者血清SP-A和SP-D水平高于單純IIM組以及對照組（P＜0．05）。單純IIM組和健康對照組患者血清SP-A和SP-D水平比較差異無統計學意義（P＞0．05）。血清SP-A、SP-D之間具有較高的正相關性。②IIM-ILD患者血清SP-A、SP-D水平與年齡、肌力、ESR、C反應蛋白及肌酶無相關性。結論 SP-A和SP-D與IIM閤併ILD具有相關性，可作為IIM閤併ILD的血清學標誌，在早期診斷IIM閤併ILD方麵有一定價值。
목적：통과대특발성염성기병（IIM）합병간질성폐병（ILD）환자적혈청표면활성단백A（SP-A）화D（SP-D）적연구，탐토기여IIM합병ILD적상관성。방법채용쌍항체협심매련면역흡부시험검측SP-A화SP-D，비교단순IIM조、IIM-ILD조、대조조혈청양본SP-A화SP-D수평적차이。분석IIM-ILD조SP-A화SP-D여년령、기력、홍세포침강솔（ESR）、C반응단백（CRP）급기매지간적상관성。결과①IIM-ILD조환자혈청SP-A화SP-D수평고우단순IIM조이급대조조（P＜0．05）。단순IIM조화건강대조조환자혈청SP-A화SP-D수평비교차이무통계학의의（P＞0．05）。혈청SP-A、SP-D지간구유교고적정상관성。②IIM-ILD환자혈청SP-A、SP-D수평여년령、기력、ESR、C반응단백급기매무상관성。결론 SP-A화SP-D여IIM합병ILD구유상관성，가작위IIM합병ILD적혈청학표지，재조기진단IIM합병ILD방면유일정개치。
Objective To investigate the correlation between idiopathic inflammatory myopathy (IIM) and inter-stitial lung disease (ILD) by assessment of the levels of surfactant protein A (SP-A) and D (SP-D). Methods The lev-els of SP-A and SP-D in patients with IIM and those complicated with ILD (IIM-ILD) and healthy controls were as-sessed by using enzyme-linked immunosorbent assay. This allowed the comparison on the difference of SP-A and SP-D among the three groups and the correlation between SP-A and SP-D with age, muscular strength, erythrocyte sedimen-tation rate (ESR), C-reactive protein (CRP) and creatine kinase. Results The levels of SP-A and SP-D in patients with IIM-ILD were markedly higher than those in IIM group and the healthy control group (both P<0.05). The differ-ence in SP-A and SP-D was not statistically significant between the latter two groups (P>0.05). There was a significant positive correlation between SP-A and SP-D. The levels of SP-A and SP-D in patients with IIM-ILD were not correlat-ed with age, muscular strength, ESR, CRP and creatine kinase. Conclusion SP-A and SP-D are correlated with IIM-ILD and may be valuable for the early diagnosis of IIM-ILD.
