CAJ | 학술논문

药物依赖是当前神经科学研究的热点问题,其病因错综复杂。近年来,药物依赖与ATP结合盒 B亚家族成员1转运蛋白( ATP-binding cassette subfamily B member 1 trans-porter, ABCB1)基因多态性的关系越来越受到关注,特别是位于26号外显子区域的3435C>T。该文就阿片类药物依赖和镇痛耐受与ABCB1基因多态性的关系进行综述,对于深入阐明药物依赖的机制以及指导美沙酮个体化治疗具有重要意义。
약물의뢰시당전신경과학연구적열점문제,기병인착종복잡。근년래,약물의뢰여ATP결합합 B아가족성원1전운단백( ATP-binding cassette subfamily B member 1 trans-porter, ABCB1)기인다태성적관계월래월수도관주,특별시위우26호외현자구역적3435C>T。해문취아편류약물의뢰화진통내수여ABCB1기인다태성적관계진행종술,대우심입천명약물의뢰적궤제이급지도미사동개체화치료구유중요의의。
Drug dependence has been a hot topic in neuroscience research due to its complicated pathogenesis. Recently, huge scientific efforts have been continuously put into understanding the association between drug dependence and polymorphism in ATP-binding cassette subfamily B member 1 transporter ( ABCB1 ) gene, especially a mutation in exon 26 at position 3435 (3435C>T). This article reviews the relationship between opioid dependence and analgesic tolerance and ABCB1 gene pol-ymorphism, which will shed light on the underlying mechanisms of drug dependence and optimal MMT programs for individuals.