CAJ | 학술논문

肠道菌群是机体重要的组成部分，正常状况下肠道菌群保持稳态，在促进营养物质消化吸收、维持肠道正常生理功能、调节机体免疫等众多生命活动中发挥重要的作用。但当体内外环境发生改变，如年龄、饮食习惯、肥胖等代谢性疾病以及抗生素等药物均会造成菌群失调。近年来，很多研究发现肠道菌群失调可以引发多种疾病，其中结肠癌的发生、发展与肠道菌群失调关系密切。同时，有研究资料表明，通过改善肠道菌群的失调状态可降低结肠癌的发生率和抑制结肠癌的生长恶化，但是具体的作用机制尚无清晰的认识。该文就近年来国内外关于肠道菌群失调与结肠癌发生、发展研究的有关热点问题及治疗进行概述，为肠道菌群研究和结肠癌的治疗提供理论参考。
장도균군시궤체중요적조성부분，정상상황하장도균군보지은태，재촉진영양물질소화흡수、유지장도정상생리공능、조절궤체면역등음다생명활동중발휘중요적작용。단당체내외배경발생개변，여년령、음식습관、비반등대사성질병이급항생소등약물균회조성균군실조。근년래，흔다연구발현장도균군실조가이인발다충질병，기중결장암적발생、발전여장도균군실조관계밀절。동시，유연구자료표명，통과개선장도균군적실조상태가강저결장암적발생솔화억제결장암적생장악화，단시구체적작용궤제상무청석적인식。해문취근년래국내외관우장도균군실조여결장암발생、발전연구적유관열점문제급치료진행개술，위장도균군연구화결장암적치료제공이론삼고。
Intestinal microflora is an important part of the organ-ism, promoting digestion and absorption of nutrients, maintaining intestinal normal physiological function, regulating immune sys-tem. Intestinal microflora maintains steady state under normal conditions, but intestinal microbiota dysbiosis occurs when surrounding environment c hanges, such as age, diet, obesity and other metabolic diseases as well as antibiotics. Many recent studies have found intestinal flora could cause a variety of disea-ses, and colon cancer is closely related with intestinal microbiota dysbiosis. Some researches suggest improving the intestinal flora dysbiosis can reduce the incidence of colon cancer and inhibit the growth and the worsening of colon cancer. However, under-lying mechanisms remain unknown. So this article summarizes the research progress on the development of colon cancer and in-testinal microbiota dysbiosis, in order to provide reference for re-search on intestinal flora and colon cancer treatment.