CAJ | 학술논문

丹参酮类是从传统中药丹参( Salvia miltiorrhiza Bunge)及其同属植物中分离到的一大类脂溶性天然产物，包括丹参酮ⅡA、隐丹参酮、丹参酮I、二氢丹参酮I等多种成分。丹参酮类与丹酚酸类均被证实是丹参的主要特征性成分和活性成分，具有较明显的心脑血管保护活性。近年来研究发现，丹参酮类在体内外有较好的抗肿瘤活性。该文就丹参酮类化合物尤其是丹参酮ⅡA的抗肿瘤作用与机制的最新研究进展作一综述，以期为该类化合物的研究和开发提供参考。
단삼동류시종전통중약단삼( Salvia miltiorrhiza Bunge)급기동속식물중분리도적일대류지용성천연산물，포괄단삼동ⅡA、은단삼동、단삼동I、이경단삼동I등다충성분。단삼동류여단분산류균피증실시단삼적주요특정성성분화활성성분，구유교명현적심뇌혈관보호활성。근년래연구발현，단삼동류재체내외유교호적항종류활성。해문취단삼동류화합물우기시단삼동ⅡA적항종류작용여궤제적최신연구진전작일종술，이기위해류화합물적연구화개발제공삼고。
Tanshinones are a large class of hydrophobic natural products isolated from traditional Chinese herb Salvia miltiorrhiza Bunge and related plants. Tanshinones include tanshinone ⅡA, cryptotanshinone, tanshinone I, dihydrotanshinone, and so on. Both the tanshinones and the salvianolic acids have been identi-fied as the characteristic and main active ingredients of Salvia miltiorrhiza Bunge with cardiovascular protective activities. Ac-cumulated data in recent years have revealed that tanshinones possess remarkable anti-cancer activities both in vivo and in vitro. In this review, we summarize the latest progress of the an-ti-cancer effect and the underlying mechanisms of tanshinones, particularly with emphasis on tanshinone ⅡA, which might pro-vide reference for the further research and development of these compounds.