CAJ | 학술논문

目的：分析急性痘疮样苔藓样糠疹(PLEVA)临床特征和疗效。方法：对64例 PLEVA 患者进行回顾性分析。结果：(1)64例患者中男女发病率之比为4.3∶1；(2)29.69％的患者发病前有感染史,93.75％的患者皮损具有多形性,43.75％症状较重者出现白细胞计数、转氨酶、免疫球蛋白(IgM、IgG、IgA)等实验室检查指标异常；(3)组织病理：淋巴细胞性血管炎,淋巴细胞、红细胞游入表皮为特征；(4)糖皮质激素、窄波中波紫外线(NB-UVB)、雷公藤多苷、四环素、甘草酸二胺等联合治疗有效。结论： PLEVA 临床表现多样性,治疗以糖皮质激素为主。
목적：분석급성두창양태선양강진(PLEVA)림상특정화료효。방법：대64례 PLEVA 환자진행회고성분석。결과：(1)64례환자중남녀발병솔지비위4.3∶1；(2)29.69％적환자발병전유감염사,93.75％적환자피손구유다형성,43.75％증상교중자출현백세포계수、전안매、면역구단백(IgM、IgG、IgA)등실험실검사지표이상；(3)조직병리：림파세포성혈관염,림파세포、홍세포유입표피위특정；(4)당피질격소、착파중파자외선(NB-UVB)、뢰공등다감、사배소、감초산이알등연합치료유효。결론： PLEVA 림상표현다양성,치료이당피질격소위주。
Objective: To analyze the clinical features and treatment of pityriasis lichenoides et variolifor-mis acuta (PLEVA). Methods: We retrospectively analyzed the clinical and laboratory data of 64 patients di-agnosed as PLEVA. Results: (1) The ratio between male and female was 4.3 ∶1. (2) 29.69% of the patients had an infection history before the onset of the disease. Pleomorphic skin lesions, such as erythema, papules, necrosis, ulceration, et al were seen in 93.75% of the patients. The abnormal laboratory tests such as white blood cell count, aminotransferase, immunoglobulin (IgM, IgG, IgA) were seen in 43.75% of severe pa-tients. (3) The pathological examination showed lymphocytic vasculitis, migration of lymphocytes and erythro-cytes into the epidermis. (4) The treatments including glucocorticoids, NB-UVB, TWP, tetracycline and gly-cyrrhizin diamine were effective. In severe PLEVA (39.06%) glucocoriticoid had been used in a combination with other drugs. Conclusion: PLEVA has a variety of clinical manifestations and steroid is till the mainstay in the treatment.