中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
7期
1042-1044
,共3页
多囊卵巢综合征%催乳素%诱发排卵
多囊卵巢綜閤徵%催乳素%誘髮排卵
다낭란소종합정%최유소%유발배란
Polycystic ovary syndrome%Prolactin%Induced ovulation
目的 探讨血清催乳素水平对于诱发排卵的多囊卵巢综合征(PCOS)患者卵泡生长的影响.方法 应用促排卵药物(克罗米芬+人绒毛膜促性腺激素)诱发PCOS患者(89例)卵泡生长,根据卵泡生长情况分为卵泡生长正常组(49例)及卵泡生长障碍组(40例).在诱发排卵的月经周期中,应用电化学发光法测定患者不同时期的卵泡大小及血清催乳素.结果 诱发卵泡生长的第0、5、10天,2组卵泡生长大小、催乳素差异均无统计学意义(均P ＞0.05),诱发卵泡生长第15天,卵泡生长正常组卵泡大小大于卵泡生长障碍组[(19.38 ±0.19)mm比(15.43±0.11) mm,t=-1.823,P＜0.05];生长正常组血清催乳素水平低于卵泡生长障碍组[(20.43 ±0.10) μg/L比(26.38 ±0.19) μg/L,t=-1.923,P＜0.05].卵泡生长障碍组患者血清催乳素激素水平与体质量、三酰甘油、血糖呈正相关(r=0.806,P＜0.05;r =0.361,P＜0.05;r=0.336,P＜0.05);卵泡生长正常组血清催乳素水平与体质量、三酰甘油、血糖呈正相关(r=0.169,P＜0.05;r =0.273,P＜0.05;r=0.184,P＜0.05).结论 卵泡生长障碍组患者血清催乳素水平较高,催乳素水平过高在一定程度上影响正常卵泡生长.
目的 探討血清催乳素水平對于誘髮排卵的多囊卵巢綜閤徵(PCOS)患者卵泡生長的影響.方法 應用促排卵藥物(剋囉米芬+人絨毛膜促性腺激素)誘髮PCOS患者(89例)卵泡生長,根據卵泡生長情況分為卵泡生長正常組(49例)及卵泡生長障礙組(40例).在誘髮排卵的月經週期中,應用電化學髮光法測定患者不同時期的卵泡大小及血清催乳素.結果 誘髮卵泡生長的第0、5、10天,2組卵泡生長大小、催乳素差異均無統計學意義(均P ＞0.05),誘髮卵泡生長第15天,卵泡生長正常組卵泡大小大于卵泡生長障礙組[(19.38 ±0.19)mm比(15.43±0.11) mm,t=-1.823,P＜0.05];生長正常組血清催乳素水平低于卵泡生長障礙組[(20.43 ±0.10) μg/L比(26.38 ±0.19) μg/L,t=-1.923,P＜0.05].卵泡生長障礙組患者血清催乳素激素水平與體質量、三酰甘油、血糖呈正相關(r=0.806,P＜0.05;r =0.361,P＜0.05;r=0.336,P＜0.05);卵泡生長正常組血清催乳素水平與體質量、三酰甘油、血糖呈正相關(r=0.169,P＜0.05;r =0.273,P＜0.05;r=0.184,P＜0.05).結論 卵泡生長障礙組患者血清催乳素水平較高,催乳素水平過高在一定程度上影響正常卵泡生長.
목적 탐토혈청최유소수평대우유발배란적다낭란소종합정(PCOS)환자란포생장적영향.방법 응용촉배란약물(극라미분+인융모막촉성선격소)유발PCOS환자(89례)란포생장,근거란포생장정황분위란포생장정상조(49례)급란포생장장애조(40례).재유발배란적월경주기중,응용전화학발광법측정환자불동시기적란포대소급혈청최유소.결과 유발란포생장적제0、5、10천,2조란포생장대소、최유소차이균무통계학의의(균P ＞0.05),유발란포생장제15천,란포생장정상조란포대소대우란포생장장애조[(19.38 ±0.19)mm비(15.43±0.11) mm,t=-1.823,P＜0.05];생장정상조혈청최유소수평저우란포생장장애조[(20.43 ±0.10) μg/L비(26.38 ±0.19) μg/L,t=-1.923,P＜0.05].란포생장장애조환자혈청최유소격소수평여체질량、삼선감유、혈당정정상관(r=0.806,P＜0.05;r =0.361,P＜0.05;r=0.336,P＜0.05);란포생장정상조혈청최유소수평여체질량、삼선감유、혈당정정상관(r=0.169,P＜0.05;r =0.273,P＜0.05;r=0.184,P＜0.05).결론 란포생장장애조환자혈청최유소수평교고,최유소수평과고재일정정도상영향정상란포생장.
Objective To analyze the relation between plasma level of prolactin and ovulation disorder in polycystic ovary syndrome (PCOS).Methods Totally 89 cases with PCOS were induced with ovulation by clomiphene and human chorionic gonadotropin during menstrual cycle of induced ovulation.The patients were divided into two groups according to ovulation [follicle growth normal group (49 cases) and follicle growth disorder group (40 cases)].The levels of prolactin were determined by electrochemical luminescence method at different follicular development period and ovulatory time.Results The levels of prolactin of two groups were different with 5 mm,10 mm,15 mm sizes during the follicular phase (all P ＞ 0.05).The different of size the follicular in follicle growth normal group was significantly larger than that in follicle growth disorder group [(19.38 ±0.19) mm vs (15.43 ± 0.11) mm,t =-1.823,P ＜0.05].The difference of the level of prolactin in follicle growth normal group was significantly lower than that in follicle growth disorder group [(20.43 ±0.10) μg/L vs (26.38 ±0.19) μg/L,t =-1.923,P ＜ 0.05].At no ovulatory term,prolactin was related to body weight,blood glucose,triglycerides (r =0.806,P ＜ 0.05 ; r =0.361,P ＜ 0.05 ; r =0.336,P ＜ 0.05).The level of prolactin of ovulatory term was related to body weight,blood glucose and triglycerides(r =0.169,P ＜ 0.05 ; r =0.273,P ＜ 0.05 ; r =0.184,P ＜ 0.05).Conclusions Patients with no ovulatory term have higher plasma levels of prolactin.High levels of prolactin may play an important role in the development of ovulatory.
