CAJ | 학술논문

目的：研究广东顺德1954～2103年用氨苯砜单疗或联合化疗后麻风病患者的复发情况。方法对1954～2013年顺德开展麻风病防治工作较完整的麻风个案资料进行分析。结果1954～2013年间顺德累计复发患者64例，累计复发率为4.77％。平均治愈-复发间隔为（131.52±12.64）个月。多菌型的累计复发率高于少菌型的累计复发率（χ2＝76.771， p＜0.0001）。男女的复发率无统计学意义（χ2＝2.349，p＝0.125）。利福平600 mg＋氧氟沙星400 mg联合化疗治愈患者的复发率为27.27％，高于其他联合化疗方案和氨苯砜单疗的复发率（χ2＝7.974，p＝0.034）。结论采用利福平和氧氟沙星联合化疗方案治愈的患者，其复发率远高于其他化疗方案，不建议继续使用和推广。麻风复发有长期危险性，长期监测随访，有助于发现复发患者。
목적：연구엄동순덕1954～2103년용안분풍단료혹연합화료후마풍병환자적복발정황。방법대1954～2013년순덕개전마풍병방치공작교완정적마풍개안자료진행분석。결과1954～2013년간순덕루계복발환자64례，루계복발솔위4.77％。평균치유-복발간격위（131.52±12.64）개월。다균형적루계복발솔고우소균형적루계복발솔（χ2＝76.771， p＜0.0001）。남녀적복발솔무통계학의의（χ2＝2.349，p＝0.125）。리복평600 mg＋양불사성400 mg연합화료치유환자적복발솔위27.27％，고우기타연합화료방안화안분풍단료적복발솔（χ2＝7.974，p＝0.034）。결론채용리복평화양불사성연합화료방안치유적환자，기복발솔원고우기타화료방안，불건의계속사용화추엄。마풍복발유장기위험성，장기감측수방，유조우발현복발환자。
Objective To study on leprosy relapse cases after DDS or MDT in Shunde City from 1954 to 1998. Methods The data of leprosy relapse cases in Shunde City from 1954 to 1998 were analyzed.Results There were a total of 64 leprosy relapse cases during 1954~1998 in Shunde City, and the relapse rate was 4.77%.The average of cure and Re-currence time were (131.52 ±12.64) months.The relapse rate of MB cases were higher than PB cases (χ2 =76.771, p<0.000 1).The relapse rate for male and female were not statistical significance (χ2 =2.349, p=0.125).The relapse rate of Chemotherapy with RFP (600 mg) and OFLO (400 mg) was 27.27%.It was higher than other treatment plans (χ2=7.974,p=0.034).Conclusion The relapse rate of Chemotherapy with RFP and OFLO were higher than other kinds of treat-ment plans, and it not recommended again.Long-term follow-up can help us to find relapse cases.