CAJ | 학술논문

中医药治疗骨性关节炎( osteoarthritis,OA)具有较大的潜力与优势,疗效确切、价格低廉、使用方便,克服了西药价格昂贵、副作用大、难以长期服用、依从性较差、治疗效果不佳的特点,开发应用前景广阔,但其具体作用机制尚不完全明确。本文通过对近五年的中医药治疗骨性关节炎作用机制研究相关文献的整理,从细胞因子、氧自由基、基质金属蛋白酶及炎症介质等相关因子、信号转导通路、软骨细胞凋亡、软骨下骨重塑等多方面概述了中医药治疗OA作用机制的研究进展。
중의약치료골성관절염( osteoarthritis,OA)구유교대적잠력여우세,료효학절、개격저렴、사용방편,극복료서약개격앙귀、부작용대、난이장기복용、의종성교차、치료효과불가적특점,개발응용전경엄활,단기구체작용궤제상불완전명학。본문통과대근오년적중의약치료골성관절염작용궤제연구상관문헌적정리,종세포인자、양자유기、기질금속단백매급염증개질등상관인자、신호전도통로、연골세포조망、연골하골중소등다방면개술료중의약치료OA작용궤제적연구진전。
Treating osteoarthritis with traditional Chinese medicine has a large potential and advan-tages such as low cost and curative effect,and convenience. It overcomes the weaknesses of taking western medicine such as high cost, big side effect, difficulty of taking for long time, poor complicance, etc. . Therefore,treating osteoarthritis with traditional chiense medicine has bright prospect for the development and application,but the mechanism of action is still not completely clear. This paper sorted out the litera-tures in recent five years,which summarized the related factors like cytokines, oxygen free radicals,matrix metallo proteinase and cytokines, signal transduction pathway, cartilage cells apoptosis. The subchondral bone restore such as studied the mechanism of action in treating osteoarthritis with traditional Chinese medi-cine.