临床肺科杂志
臨床肺科雜誌
림상폐과잡지
JOUNAL OF CLINICAL PULMONARY MEDICINE
2014年
9期
1667-1669
,共3页
肺腺癌%肿瘤标记物%癌胚抗原( CEA)%糖链抗原%联合测定
肺腺癌%腫瘤標記物%癌胚抗原( CEA)%糖鏈抗原%聯閤測定
폐선암%종류표기물%암배항원( CEA)%당련항원%연합측정
lung adenocarcinoma%tumor marker%carcinoembryonic antigen ( CEA)%carbohydrate antigen%combined determination
目的：为了探讨85例肺腺癌患者血清CEA和糖链抗原肿瘤标记物水平联合测定的临床意义。方法化学发光免疫分析测定85例肺腺癌、35例肺鳞癌、42例小细胞肺癌和49例良性肺部疾病血清CEA和糖链抗原(CA125、CA199和CA153)水平,并进行了比较性研究。结果162例肺癌患者中,85例肺腺癌、35例肺鳞癌、42例小细胞肺癌患者血清CEA水平较之49例良性肺部疾病明显增高( P<0．001、P<0．01和P<0．001),以肺腺癌增高最为明显。血清糖链抗原(CA125、CA199和 CA153)水平亦然,也以肺腺癌血清CA125、CA199和CA153水平增高最为显著。四项肿瘤标记物的联合测定对85例肺腺癌的敏感性为95．29%和准确性83．76%较之单项肿瘤标记物明显增高(P均<0．01),而特异性为75．23%适中。结论四项肿瘤标记物血清CEA和糖链抗原( CA125、CA199和CA153)水平的联合测定,是诊断肺腺癌的有效指标,而且提高了敏感性和准确性。
目的：為瞭探討85例肺腺癌患者血清CEA和糖鏈抗原腫瘤標記物水平聯閤測定的臨床意義。方法化學髮光免疫分析測定85例肺腺癌、35例肺鱗癌、42例小細胞肺癌和49例良性肺部疾病血清CEA和糖鏈抗原(CA125、CA199和CA153)水平,併進行瞭比較性研究。結果162例肺癌患者中,85例肺腺癌、35例肺鱗癌、42例小細胞肺癌患者血清CEA水平較之49例良性肺部疾病明顯增高( P<0．001、P<0．01和P<0．001),以肺腺癌增高最為明顯。血清糖鏈抗原(CA125、CA199和 CA153)水平亦然,也以肺腺癌血清CA125、CA199和CA153水平增高最為顯著。四項腫瘤標記物的聯閤測定對85例肺腺癌的敏感性為95．29%和準確性83．76%較之單項腫瘤標記物明顯增高(P均<0．01),而特異性為75．23%適中。結論四項腫瘤標記物血清CEA和糖鏈抗原( CA125、CA199和CA153)水平的聯閤測定,是診斷肺腺癌的有效指標,而且提高瞭敏感性和準確性。
목적：위료탐토85례폐선암환자혈청CEA화당련항원종류표기물수평연합측정적림상의의。방법화학발광면역분석측정85례폐선암、35례폐린암、42례소세포폐암화49례량성폐부질병혈청CEA화당련항원(CA125、CA199화CA153)수평,병진행료비교성연구。결과162례폐암환자중,85례폐선암、35례폐린암、42례소세포폐암환자혈청CEA수평교지49례량성폐부질병명현증고( P<0．001、P<0．01화P<0．001),이폐선암증고최위명현。혈청당련항원(CA125、CA199화 CA153)수평역연,야이폐선암혈청CA125、CA199화CA153수평증고최위현저。사항종류표기물적연합측정대85례폐선암적민감성위95．29%화준학성83．76%교지단항종류표기물명현증고(P균<0．01),이특이성위75．23%괄중。결론사항종류표기물혈청CEA화당련항원( CA125、CA199화CA153)수평적연합측정,시진단폐선암적유효지표,이차제고료민감성화준학성。
Objective To explore the clinical significant of combined determination of serum CEA and car-bohydrate antigen (CA125, CA199, CA153) tumor markers in patients with lung adenocarcinoma. Methods The serum CEA and carbohydrate antigen (CA125, CA199 and CA153) levels were determined with chemilumescence immunoassay in 85 patients with lung adenocarcinoma, 35 patients with lung squanous carcinoma, 42 patients with small cell lung cancer and 49 patients with benign lung disease. Results In 162 patients with lung cancer, the ser-um CEA and carbohydrate antigen levels were significantly higher in 85 patients with lung adenocarcinoma, 35 pa-tients with lung squanous carcinoma and 42 patients with small cell lung cancer than those in 49 patients with benign lung disease (P<0. 001) and the level of 85 patients with lung adenocarcinoma was the highest. So did the serum carbohydrate antigen levels. The sensitivity (95. 29%) and accuracy (83. 76%) in the four tumor markers combined determination were significantly higher than those in single item ( P all<0. 01 ) , and the specificity was 75. 23%. Conclusion The combined detection of serum CEA and carbohydrate antigen levels is helpful for the diagnosis of lung adenocarcinoma, with higher sensitivity and accuracy.
