CAJ | 학술논문

目的：研究干扰素诱导蛋白-10(IP-10,interferon-inducible protein 10)在藏族人群结核性脑膜炎患者临床诊断中的意义。方法选择30例藏族结核性脑膜炎和30例非结核性脑膜炎藏族患者,通过ELISA法检测脑脊液IP-10水平,绘制ROC曲线( receiver operating characteristic curve)确定IP-10诊断结核性脑膜炎的临界值,并评价其特异性、敏感性及诊断效能。结果结核性脑膜炎组IP-10含量为(1160．06±468．05) pg/ml,显著高于非结核性脑膜炎组(242．80±166．47)pg/ml,差异具有统计学意义(P<0．001)。 IP-10诊断藏族人群结核性脑膜炎的临界值为605．62 pg/ml,敏感性为86．7%,特异性为96．7%；通过比较ROC曲线下面积大小,提示IP-10的诊断效能和γ-干扰素接近。结论脑脊液中IP-10水平测定有助于藏族人群结核性脑膜炎的临床诊断。
목적：연구간우소유도단백-10(IP-10,interferon-inducible protein 10)재장족인군결핵성뇌막염환자림상진단중적의의。방법선택30례장족결핵성뇌막염화30례비결핵성뇌막염장족환자,통과ELISA법검측뇌척액IP-10수평,회제ROC곡선( receiver operating characteristic curve)학정IP-10진단결핵성뇌막염적림계치,병평개기특이성、민감성급진단효능。결과결핵성뇌막염조IP-10함량위(1160．06±468．05) pg/ml,현저고우비결핵성뇌막염조(242．80±166．47)pg/ml,차이구유통계학의의(P<0．001)。 IP-10진단장족인군결핵성뇌막염적림계치위605．62 pg/ml,민감성위86．7%,특이성위96．7%；통과비교ROC곡선하면적대소,제시IP-10적진단효능화γ-간우소접근。결론뇌척액중IP-10수평측정유조우장족인군결핵성뇌막염적림상진단。
Objective To evaluate the significance of interferon-inducible protein 10 ( IP-10 ) level in the cerebrospinal fluid for the diagnosis of Tibetan tuberculous meningitis. Methods Enzyme-linked immunosorbent as-say ( ELISA) was adopted to detect the level of IP-10 in the cerebrospinal fluid of 30 Tibetan patients with tubercu-lous meningitis and 30 Tibetan patients with non-tuberculous meningitis. The receiver operating characteristic ( ROC) curves were used to detect the cut-off value and analyze the specificity, sensitivity and diagnostic efficiency. Results The concentration of IP-10 was significantly higher in the study group (1160. 06 ± 468. 05 pg/ml) than in the con-trol group (242. 80 ± 166. 47) (P<0. 001). When 605. 62pg/ml was used as cut-off value, the sensitivity and spe-cificity for IP-10 in diagnosis of Tibetan tuberculous meningitis were 86. 7% and 96. 7%, respectively. And the diag-nostic efficiency of IP-10 was similar to that of IFN-γ. Conclusion The detection of IP-10 in the Tibetan cerebrospi-nal fluid is helpful in the diagnosis of tuberculous meningitis.