CAJ | 학술논문

目的：探讨踝臂指数（ABI）、血清超敏C反应蛋白（hs-CRP）与老年帕金森病合并轻度认知损害（ PD-MCI ）的关系。方法89例老年帕金森病患者，其中合并轻度认知损害43例（ PD-MCI组），无合并轻度认知损害46例（单纯PD组），健康对照组46例，采用全自动动脉硬化BP203RPE-II检测仪检测各组对象ABI，采用酶比色法测定血清hs-CRP水平。结果 PD-MCI组、单纯PD组患者ABI均低于对照组（P＜0．05），PD-MCI组与单纯PD组ABI比较，差异无统计学意义（ P＞0．05）。 PD-MCI组hs-CRP水平高于对照组、单纯PD组（P＜0．05），单纯PD组hs-CRP水平与对照组比较，差异无统计学意义（P＞0．05）。结论老年帕金森病患者ABI下降，PD-MCI患者血hs-CRP水平升高。 hs-CRP水平升高可能是反映PD-MCI的指标。
목적：탐토과비지수（ABI）、혈청초민C반응단백（hs-CRP）여노년파금삼병합병경도인지손해（ PD-MCI ）적관계。방법89례노년파금삼병환자，기중합병경도인지손해43례（ PD-MCI조），무합병경도인지손해46례（단순PD조），건강대조조46례，채용전자동동맥경화BP203RPE-II검측의검측각조대상ABI，채용매비색법측정혈청hs-CRP수평。결과 PD-MCI조、단순PD조환자ABI균저우대조조（P＜0．05），PD-MCI조여단순PD조ABI비교，차이무통계학의의（ P＞0．05）。 PD-MCI조hs-CRP수평고우대조조、단순PD조（P＜0．05），단순PD조hs-CRP수평여대조조비교，차이무통계학의의（P＞0．05）。결론노년파금삼병환자ABI하강，PD-MCI환자혈hs-CRP수평승고。 hs-CRP수평승고가능시반영PD-MCI적지표。
Objective To study the relationship between ankle-brachial index(ABI),serum high-sensitivity C -reactive protein(hs-CRP) and elderly Parkinson′s disease with mild cognitive impairment (PD-MCI).Methods Eighty-nine cases of elder Parkinson′s disease were divided into 2 groups:43 cases with mild cognitive impairment ( PD-MCI group ) and 46 cases without mild cognitive impairment ( pure PD group ) ,respectively .Forty-six cases of the healthy elders were selected as control group .ABI of all observers was detected by full-automatic arteriosclerosis ( BP203 RPE-Ⅱ) ,and serum hs-CRP level was examined by enzyme colorimetry .Results The ABI in the PD-MCI group,pure PD group was lower than that in the control group (P<0.05).The ABI showed no significant difference between PD-MCI group and pure PD group (P>0.05).The hs-CRP level in the PD-MCI group was higher than that in the control group or pure PD group (P<0.05),while the hs-CRP level showed no significant difference between pure PD group and control group(P>0.05).Conclusion Lower ABI can be observed in elderly patients with Parkinson′s disease.The hs-CRP level increases in PD-MCI patients,which indicates the increase of hs-CRP level may be an index of PD-MCI .