CAJ | 학술논문

目的：了解耐多药肺结核患者对二线抗结核药物的耐药情况。方法对我院住院的341例耐多药肺结核患者二线抗结核药物的耐药情况进行分析。结果341例MDR-TB对左氧氟沙星、丙硫异烟胺、力克肺疾、对氨基水杨酸、丁胺卡那霉素、卷曲霉素的总耐药率依次为49．9%、26．4%、24．9%、23．4%、18．5%、15．8%。复治组对二线抗结核药物的耐多药率明显高于初治组，不合理治疗是形成MDR-TB或XDR-TB的主要原因。结论耐多药肺结核患者对二线抗结核药物耐药情况严重，要引起重视。
목적：료해내다약폐결핵환자대이선항결핵약물적내약정황。방법대아원주원적341례내다약폐결핵환자이선항결핵약물적내약정황진행분석。결과341례MDR-TB대좌양불사성、병류이연알、력극폐질、대안기수양산、정알잡나매소、권곡매소적총내약솔의차위49．9%、26．4%、24．9%、23．4%、18．5%、15．8%。복치조대이선항결핵약물적내다약솔명현고우초치조，불합리치료시형성MDR-TB혹XDR-TB적주요원인。결론내다약폐결핵환자대이선항결핵약물내약정황엄중，요인기중시。
Objective To study the drug resistance of MDR-TB patients to second-line drug. Methods The drug resistance of 341 MDR-TB patients to second-line drug was analyzed in our hospital. Results The drug re-sistance rate of 341 MDR-TB patients to levofloxacin, prothionamide, isoniazid aminosalicylate, P-aminosalicylic acid, amikacin and capreomycin were 49. 9%, 26. 4%, 24. 9%, 3. 4%, 18. 5% and 15. 8% respectively. The multi-drug resistant rate of second-line anti-TB drugs in the retreatment group was higher than that in the initial treat-ment group. Unreasonable treatment was the main reason for the formation of MDR-TB or XDR-TB. Conclusion The drug resistance of MDR-TB patients to second-line drug is in serious condition, which must be paid more atten-tion.