CAJ | 학술논문

目的：探讨不同麻醉方法对腹腔镜胆囊手术患者C反应蛋白（CRP）及补体C3、C4水平的影响。方法46例择期行腹腔镜胆囊摘除术患者，随机分为两组，每组23例，A组为静吸复合麻醉组，B组为静吸复合麻醉＋硬膜外麻醉组。分别在麻醉诱导前（T1）、手术结束时（T2）、手术后24h（T3）及72h（T4）抽取血样，测定CRP、C3、C4水平。结果A组患者血清CRP、C3、C4水平高于B组（P＜0．05）；不同时间点的CRP、C3、C4水平不全相同（P＜0．05）。结论硬膜外阻滞麻醉＋静吸复合麻醉用于腹腔镜胆囊手术患者可明显减轻术中及术后应激反应，有利于补体系统的稳定。
목적：탐토불동마취방법대복강경담낭수술환자C반응단백（CRP）급보체C3、C4수평적영향。방법46례택기행복강경담낭적제술환자，수궤분위량조，매조23례，A조위정흡복합마취조，B조위정흡복합마취＋경막외마취조。분별재마취유도전（T1）、수술결속시（T2）、수술후24h（T3）급72h（T4）추취혈양，측정CRP、C3、C4수평。결과A조환자혈청CRP、C3、C4수평고우B조（P＜0．05）；불동시간점적CRP、C3、C4수평불전상동（P＜0．05）。결론경막외조체마취＋정흡복합마취용우복강경담낭수술환자가명현감경술중급술후응격반응，유리우보체계통적은정。
Objective To investigate the effects of different anesthesia methods on C-reactive protein ( CRP) and complement C3,C4 level in patients undergoing laparoscopic cholecystectomy .Methods Forty-six patients of laparoscopic holecystectomy were randomly divided into two groups ,with 23 cases in each group.Group A was given inhalation anesthesia ,and group B was given inhalation +epidural anesthesia .The blood samples were collected before induction of anesthesia(T1),at the end of surgery(T2),24 hours(T3) and 72 hours(T4) after surgery,respectively,to measure the levels of CRP,C3,C4.Results The serum CRP,C3,C4 levels in group A were significantly higher than those in group B(P<0.05).Different CRP,C3,C4 levels were found at different time points(P<0.05).Conclusion The combination of epidural and inhalation anesthesia for laparoscopic gallbladder surgery can significantly reduce stress response during intraoperative and postoperative period ,and it is helpful to stabilize the complement systems .