北方药学
北方藥學
북방약학
JOURNAL OF NORTH PHARMACY
2014年
9期
86-87
,共2页
依达拉奉%对比剂肾病%血清肌酐(Scr)%内生肌酐清除率(Ccr)
依達拉奉%對比劑腎病%血清肌酐(Scr)%內生肌酐清除率(Ccr)
의체랍봉%대비제신병%혈청기항(Scr)%내생기항청제솔(Ccr)
Edaravone%Contrast induced nephropathy%Serum creatinine%Endogenous creatinine clearance rate
目的:探讨依达拉奉在冠脉介入术前后对比剂肾病中的防治作用。方法:将150例行冠状动脉介入术诊断及治疗的患者随机分为依达拉奉组(75例)及对照组(75例),在全部采用水化治疗基础上,依达拉奉组在冠脉介入术当日开始给予依达拉奉30mg稀释后30min滴完,1次/12h,连续5d。观察术前、术后血清肌酐(Scr)、内生肌酐清除率(Cer),血β2-微球蛋白(β2-M)、丙二醛(MDA)的含量和超氧化物歧化酶(SOD)的活性改变情况。结果:术后第1d、3d、5d,两组Cer与术前相比明显下降,Scr、β2-M分别与术前比较均明显升高(P<0.05)。组间比较,对照组Cer较依达拉奉组低,差异有统计学意义,而Scr、β2-M明显升高(P<0.05)。术后第1d、3d、5d依达拉奉组MDA含量较对照组明显降低(P<0.05),而SOD活性显著增加(P<0.05)。结论:冠脉介入术前后使用依达拉奉可能有助于减少对比剂肾病的发生,机制可能与清除氧自由基有关。
目的:探討依達拉奉在冠脈介入術前後對比劑腎病中的防治作用。方法:將150例行冠狀動脈介入術診斷及治療的患者隨機分為依達拉奉組(75例)及對照組(75例),在全部採用水化治療基礎上,依達拉奉組在冠脈介入術噹日開始給予依達拉奉30mg稀釋後30min滴完,1次/12h,連續5d。觀察術前、術後血清肌酐(Scr)、內生肌酐清除率(Cer),血β2-微毬蛋白(β2-M)、丙二醛(MDA)的含量和超氧化物歧化酶(SOD)的活性改變情況。結果:術後第1d、3d、5d,兩組Cer與術前相比明顯下降,Scr、β2-M分彆與術前比較均明顯升高(P<0.05)。組間比較,對照組Cer較依達拉奉組低,差異有統計學意義,而Scr、β2-M明顯升高(P<0.05)。術後第1d、3d、5d依達拉奉組MDA含量較對照組明顯降低(P<0.05),而SOD活性顯著增加(P<0.05)。結論:冠脈介入術前後使用依達拉奉可能有助于減少對比劑腎病的髮生,機製可能與清除氧自由基有關。
목적:탐토의체랍봉재관맥개입술전후대비제신병중적방치작용。방법:장150례행관상동맥개입술진단급치료적환자수궤분위의체랍봉조(75례)급대조조(75례),재전부채용수화치료기출상,의체랍봉조재관맥개입술당일개시급여의체랍봉30mg희석후30min적완,1차/12h,련속5d。관찰술전、술후혈청기항(Scr)、내생기항청제솔(Cer),혈β2-미구단백(β2-M)、병이철(MDA)적함량화초양화물기화매(SOD)적활성개변정황。결과:술후제1d、3d、5d,량조Cer여술전상비명현하강,Scr、β2-M분별여술전비교균명현승고(P<0.05)。조간비교,대조조Cer교의체랍봉조저,차이유통계학의의,이Scr、β2-M명현승고(P<0.05)。술후제1d、3d、5d의체랍봉조MDA함량교대조조명현강저(P<0.05),이SOD활성현저증가(P<0.05)。결론:관맥개입술전후사용의체랍봉가능유조우감소대비제신병적발생,궤제가능여청제양자유기유관。
Objective:To investigate the efficacy of edaravone on preventing contrast induced nephropathy (CIN). Methods:150 patients underwent coronary angiography were randomized to the edaravone prevention group and control group. 75 patients in experiment group were treated with edaravone 30mg on the basis of hydrated therapy ,edaravone was diluted and intravenous infusion to each patient in 30min ,once every 12 hours for 5 days. Serum creatinine(Scr), endogenous creatinine clearance rate(Cer), Bloodβ2-microglobulin(β2-M), malo ndiald ehyde (MDA), super -oxide dismutase (SOD)before and after the procedure were compared between the groups. Results:After day 1,day 3 and day 5,two groups of Cer significantly decreased when compared with those of preoperation (P<0.05),and Scr、B2-M,significantly increased (P<0.05),and those in edaravone prevention group were higher than those in control group (P<0.05). After day 1,day 3 and day 5 ,the content of MDA were significantly decreased, and the activity of SOD were obviously increased in edaravone treatment group compared with control group when compared with those of preoperation (P<0.05). Conclusion:Edaravone use before and after angiography can reduce the incidence of CIN, which might be involved in scavenging the oxygen free.