CAJ | 학술논문

目的：探讨不同剂量沐舒坦对改善急性加重期慢性阻塞性肺病（AECOPD）患者肺功能的效果。方法将102例AECO-PD患者随机分为3组，分别为对照组32例：给予支气管扩张剂、常规吸氧及抗生素静脉滴注治疗，7 d为1疗程；沐舒坦常规剂量组35例：在对照组的基础上给予剂量为30 mg/次沐舒坦静脉滴注治疗，每天3次，7 d为1疗程；沐舒坦大剂量组35例：在对照组的基础上给予剂量为150 mg/次沐舒坦静脉滴注，每天2次，7 d为1疗程。对比分析三组治疗前后肺功能指标、血气指标及总有效率。结果三组患者治疗后肺功能指标均得到改善，其中大剂量组治疗后FEV1．0、PEF 以及FEV1．0/FVC、6MWD水平显著高于常规剂量组及对照组，两两比较有统计学意义（P＜0．05）。大剂量组治疗后SaO2、PaO2、PaO2/FiO2水平显著高于常规剂量组及对照组，两两比较差异有统计学意义（P＜0．05）。大剂量组总有效率为94．28％，常规剂量组总有效率为82．86％，对照组总有率为78．13％，两两比较差异有统计学意义（P＜0．05）。大剂量组不良反应4例（11．43％），常规剂量组不良反应3例（9．37％），对照组不良反应2例（6．25％），不良反应率两两比较无统计学差异。结论大剂量沐舒坦能有效改善AECOPD患者肺功能指标及血气指标，疗效显著，不良反应率低。
목적：탐토불동제량목서탄대개선급성가중기만성조새성폐병（AECOPD）환자폐공능적효과。방법장102례AECO-PD환자수궤분위3조，분별위대조조32례：급여지기관확장제、상규흡양급항생소정맥적주치료，7 d위1료정；목서탄상규제량조35례：재대조조적기출상급여제량위30 mg/차목서탄정맥적주치료，매천3차，7 d위1료정；목서탄대제량조35례：재대조조적기출상급여제량위150 mg/차목서탄정맥적주，매천2차，7 d위1료정。대비분석삼조치료전후폐공능지표、혈기지표급총유효솔。결과삼조환자치료후폐공능지표균득도개선，기중대제량조치료후FEV1．0、PEF 이급FEV1．0/FVC、6MWD수평현저고우상규제량조급대조조，량량비교유통계학의의（P＜0．05）。대제량조치료후SaO2、PaO2、PaO2/FiO2수평현저고우상규제량조급대조조，량량비교차이유통계학의의（P＜0．05）。대제량조총유효솔위94．28％，상규제량조총유효솔위82．86％，대조조총유솔위78．13％，량량비교차이유통계학의의（P＜0．05）。대제량조불량반응4례（11．43％），상규제량조불량반응3례（9．37％），대조조불량반응2례（6．25％），불량반응솔량량비교무통계학차이。결론대제량목서탄능유효개선AECOPD환자폐공능지표급혈기지표，료효현저，불량반응솔저。
Objective To investigate the effects of different doses of ambroxol on lung function of patients with acute exacerbation ofchronic obstructive pulmonary disease (AECOPD).Methods A hundred and two cases of AECOPD patients were randomly assignedinto control group(n =32),treated with bronchodilators,conventional oxygen and intravenous antibiotic therapy for 7 d,mucosolvan con-ventional-dose group(n =35),treated with mucosolvan intravenous infusion therapy(3 times/d)for 7 d,and mucosolvan high dosegroup(n =35),treated with 150 mg/times mucosolvan(2 times/d)for 7 d.The total effective rate,lung functions and blood indices ofthree groups before and after treatment were compared.Results Lung functions of all three groups were improved after treatment.Thelevels of FEV1.0 %,PEF% and FEV1.0 /FVC,6MWD of high-dose group were higher than the conventional dose group and the controlgroup (P <0.05).The levels of SaO2 ,PaO2 ,PaO2 /FiO2 of high-dose group were higher than the conventional dose group and the con-trol group after the treatment(P <0.05).The total effective rates of high-dose group,conventional dose group and control group were94.28%,82.86% and 78.13%,respectively(P <0.05).There were 4 cases (11.43%),3 cases (9.37%),and 2 cases (6.25%)of adverse reactions in high-dose group,conventional dose group and control group,respectively.The adverse reaction rates were not sta-tistically significant(P >0.05).Conclusions High-dose ambroxol can effectively improve lung function and blood gas in patients withAECOPD,which achieves significant effects with less adverse reactions.