CAJ | 학술논문

目的：探讨芪苈强心胶囊治疗慢性心衰的临床疗效和安全性。方法选择符合慢性心衰NYHA分级Ⅱ～Ⅳ患者60例，随机分为对照组和治疗组，对照组30例，治疗组30例，对照组常规使用血管紧张素酶抑制剂、β-受体阻滞剂、利尿剂和地高辛等治疗，治疗组30例在常规治疗基础上加用芪苈强心胶囊，每次4粒，每天3次，疗程12周。两组治疗前后行超声心动图检查，测量并计算左室舒张末期内径（LVEDd），左室收缩末期内径（LVEDs）、室间隔厚度（IVSd）、左室后壁厚度（LVPWd）、左室射血分数（LVEF）、左室心肌质量（LVM）、左室心肌质量指数（LVMI）。比较组内治疗前后上述超声心动图指标的变化和组间差异。结果治疗组和对照组治疗12周后，两组LVEDd，LVEDs、IVSd、LVPWd、LVM、LVMI、LVEF均有明显改善，治疗前后差异有统计学意义（P＜0．05）。治疗组和对照组比较，治疗后，治疗组的LVEDd，LVEDs、IVSd、LVPWd、LVM、LVMI、LVEF较对照组改善更明显，两组间差异有统计学意义（P＜0．05）。结论慢性心力衰竭患者在常规药物治疗的基础上加用芪苈强心胶囊，能明显的改善患者的心功能、改善左室重构。
목적：탐토기력강심효낭치료만성심쇠적림상료효화안전성。방법선택부합만성심쇠NYHA분급Ⅱ～Ⅳ환자60례，수궤분위대조조화치료조，대조조30례，치료조30례，대조조상규사용혈관긴장소매억제제、β-수체조체제、이뇨제화지고신등치료，치료조30례재상규치료기출상가용기력강심효낭，매차4립，매천3차，료정12주。량조치료전후행초성심동도검사，측량병계산좌실서장말기내경（LVEDd），좌실수축말기내경（LVEDs）、실간격후도（IVSd）、좌실후벽후도（LVPWd）、좌실사혈분수（LVEF）、좌실심기질량（LVM）、좌실심기질량지수（LVMI）。비교조내치료전후상술초성심동도지표적변화화조간차이。결과치료조화대조조치료12주후，량조LVEDd，LVEDs、IVSd、LVPWd、LVM、LVMI、LVEF균유명현개선，치료전후차이유통계학의의（P＜0．05）。치료조화대조조비교，치료후，치료조적LVEDd，LVEDs、IVSd、LVPWd、LVM、LVMI、LVEF교대조조개선경명현，량조간차이유통계학의의（P＜0．05）。결론만성심력쇠갈환자재상규약물치료적기출상가용기력강심효낭，능명현적개선환자적심공능、개선좌실중구。
Objective To explore clinical therapeutic effect and safety of QiliQiangxin capsule in the treatment of chronic heart failure(CHF).Methods Sixty chronic heart faliure patients with NYHA functional classification Ⅱ-Ⅳ grade were randomly assigned intotwo groups.Thirty patients in the control group received routine treatment including angiotensin enzyme inhibitors(ACEI),beta receptorblockers,diuretic and digoxin while the other thirty patients in the treatment group received routine treatment plus QiliQiangxin capsule,four pills a time,three times a day,with a treatment course of 12 weeks.Echocardiogram was applied to the detection of the left ventricu-lar end-diastolic diameter(LVEDd),left ventricular end-systolic diameter(LVEDs),interventricular septum diameter(IVSd),left ven-tricular posterior diameter(LVPWd),left ventricular ejection fraction(LVEF),left ventricular myocardial mass(LVM)and left ventric-ular myocardial mass index(LVMI).We compared the changes and differences of the above indexes between the two groups before andafter the treatment.Results After 12 weeks of treatment,LVEDd,LVEDs,IVSd,LVWd,LVM,LVMI and LVEF were obviously im-proved both in the control group and treatment group.There were significant differences before and after the treatment(P <0.05).Afterthe treatment,LVEDd,LVEDs,IVSd,LVWd,LVM,LVMI and LVEF were better improved in the treatment group than in the controlgroup with significant differences(P <0.05).Conclusions For parients with chronic heart failure,routine treatment plus QiliQiangxincapsule can significantly improve cardiac function and left ventricular remodeling.