安徽医药
安徽醫藥
안휘의약
ANHUI MEDICAL AND PHARMACEUTICAL JOURNAL
2014年
10期
1903-1904,1905
,共3页
刘瑞凌%袁良津%李博%陈祚胜
劉瑞凌%袁良津%李博%陳祚勝
류서릉%원량진%리박%진조성
重复经颅磁刺激%帕罗西汀%抑郁症
重複經顱磁刺激%帕囉西汀%抑鬱癥
중복경로자자격%파라서정%억욱증
repetitive transcranial magnetic stimulation%paroxetine%depression
目的：评价高频重复经颅磁刺激（rTMS）左侧额叶背外侧（DLPFC）治疗抑郁症的有效性及安全性。方法将96例入组的抑郁症患者，随机分为3组，rTMS组、帕罗西汀＋假性rTMS组及帕罗西汀组。进行为期8周的随机对照研究。采用汉密尔顿抑郁量表（HAMD-24）、临床疗效总评量表（CGI）评定治疗效果。结果 rTMS组、帕罗西汀联合假性rTMS组及帕罗西汀组分别有1、2、3例患者脱落。共有90例患者完成8周治疗，治疗后各组患者HAMD-24分值、CGI-SI 分值较治疗前均有显著下降（P＜0．01）。而3组间有效率、CGI-GI比较差异无统计学意义（P＞0．05）。rTMS组、帕罗西汀＋假性rTMS组及帕罗西汀组HAMD-24有效率分别是78．13％、81．25％、75．00％，副反应发生率分别是12．5％、21．88％、21．88％，3组均未出现严重不良事件。结论高频rTMS左侧DLPFC治疗抑郁症与帕罗西汀疗效相当，且不良反应少。
目的：評價高頻重複經顱磁刺激（rTMS）左側額葉揹外側（DLPFC）治療抑鬱癥的有效性及安全性。方法將96例入組的抑鬱癥患者，隨機分為3組，rTMS組、帕囉西汀＋假性rTMS組及帕囉西汀組。進行為期8週的隨機對照研究。採用漢密爾頓抑鬱量錶（HAMD-24）、臨床療效總評量錶（CGI）評定治療效果。結果 rTMS組、帕囉西汀聯閤假性rTMS組及帕囉西汀組分彆有1、2、3例患者脫落。共有90例患者完成8週治療，治療後各組患者HAMD-24分值、CGI-SI 分值較治療前均有顯著下降（P＜0．01）。而3組間有效率、CGI-GI比較差異無統計學意義（P＞0．05）。rTMS組、帕囉西汀＋假性rTMS組及帕囉西汀組HAMD-24有效率分彆是78．13％、81．25％、75．00％，副反應髮生率分彆是12．5％、21．88％、21．88％，3組均未齣現嚴重不良事件。結論高頻rTMS左側DLPFC治療抑鬱癥與帕囉西汀療效相噹，且不良反應少。
목적：평개고빈중복경로자자격（rTMS）좌측액협배외측（DLPFC）치료억욱증적유효성급안전성。방법장96례입조적억욱증환자，수궤분위3조，rTMS조、파라서정＋가성rTMS조급파라서정조。진행위기8주적수궤대조연구。채용한밀이돈억욱량표（HAMD-24）、림상료효총평량표（CGI）평정치료효과。결과 rTMS조、파라서정연합가성rTMS조급파라서정조분별유1、2、3례환자탈락。공유90례환자완성8주치료，치료후각조환자HAMD-24분치、CGI-SI 분치교치료전균유현저하강（P＜0．01）。이3조간유효솔、CGI-GI비교차이무통계학의의（P＞0．05）。rTMS조、파라서정＋가성rTMS조급파라서정조HAMD-24유효솔분별시78．13％、81．25％、75．00％，부반응발생솔분별시12．5％、21．88％、21．88％，3조균미출현엄중불량사건。결론고빈rTMS좌측DLPFC치료억욱증여파라서정료효상당，차불량반응소。
Objective To evaluate the efficacy and safety of high frequency repetitive transcranial magnetic stimulation (rTMS)on theleft side of the frontal lobe dorsolateral (DLPFC)in the treatment of depression.Methods Ninety -six patients with depression wererandomized into three groups treated with rTMS,paroxetine combined pseudo rTMS and paroxetine.The efficacy was assessed with Ham-ilton Depression Rating scale-24 (HAMD-24)and the clinical efficacy of overall rating scale (CGI).Results The rTMS group,parox-etine combined pseudo rTMS group and paroxetine group had 1,2,3 patients fall off respectively.A total of 90 patients completed 8-week treatment.HAMD-24 ,CGI-SI score of three groups were significantly decreased when compared with the baseline (P <0.01),but there was no statistical significance between the groups (P >0.05).The effective rates of rTMS group,paroxetine combined pseudorTMS group and paroxetine group were 78.13%,81.25%,75.00% respectively.The adverse reactions were 12.5%,21.88%,21.88% respectively.All patients had not appeared serious adverse events.Conclusions High frequency rTMS in left DLPFC had similartherapeutic effects with paroxetine in the treatment of depression,which had less adverse reaction.
