安徽医药
安徽醫藥
안휘의약
ANHUI MEDICAL AND PHARMACEUTICAL JOURNAL
2014年
10期
1898-1899,1900
,共3页
人乳头瘤病毒%支链DNA技术%mRNA%宫颈癌
人乳頭瘤病毒%支鏈DNA技術%mRNA%宮頸癌
인유두류병독%지련DNA기술%mRNA%궁경암
human papillomavirus%bDNA method%mRNA%cervical cancer
目的：研究HPV E6/E7 mRNA表达与宫颈病变发展的相关性。方法采用支链 DNA（bDNA）技术检测226例宫颈活检组织中人乳头瘤病毒（HPV）E6/E7 mRNA的表达，并分析与病理分级的关系。结果不同病理诊断级别HPV E6/E7 mR-NA表达率的差异有统计学意义；不同病理分级的宫颈组织标本HPV E6/E7 mRNA表达量差异有显著性；HPV E6/E7 mRNA表达量与宫颈组织标本病理分级呈正相关。结论 HPVE6/E7mRNA检测对于宫颈病变的发展监测、预后判断等具有重要的指导意义。
目的：研究HPV E6/E7 mRNA錶達與宮頸病變髮展的相關性。方法採用支鏈 DNA（bDNA）技術檢測226例宮頸活檢組織中人乳頭瘤病毒（HPV）E6/E7 mRNA的錶達，併分析與病理分級的關繫。結果不同病理診斷級彆HPV E6/E7 mR-NA錶達率的差異有統計學意義；不同病理分級的宮頸組織標本HPV E6/E7 mRNA錶達量差異有顯著性；HPV E6/E7 mRNA錶達量與宮頸組織標本病理分級呈正相關。結論 HPVE6/E7mRNA檢測對于宮頸病變的髮展鑑測、預後判斷等具有重要的指導意義。
목적：연구HPV E6/E7 mRNA표체여궁경병변발전적상관성。방법채용지련 DNA（bDNA）기술검측226례궁경활검조직중인유두류병독（HPV）E6/E7 mRNA적표체，병분석여병리분급적관계。결과불동병리진단급별HPV E6/E7 mR-NA표체솔적차이유통계학의의；불동병리분급적궁경조직표본HPV E6/E7 mRNA표체량차이유현저성；HPV E6/E7 mRNA표체량여궁경조직표본병리분급정정상관。결론 HPVE6/E7mRNA검측대우궁경병변적발전감측、예후판단등구유중요적지도의의。
Objective To study the relationship between the quantity of HPV E6 /E7 mRNA expression and the development of cervicaldisease.Methods A total of 226 cervical biopsy specimens were taken for pathological diagnosis,and HPV E6 /E7 mRNA expressionwas determined by bDNA.Results HPV E6 /E7 mRNA in different groups had significant difference.The positive expression rates inCINI-CINIII and cervical cancer patients were higher than those of cervicitis patients.There was a positive relationship between the se-verity of cervical disease and the expression level of HPV E6 /E7mRNA.Conclusion Detection of HPV E6 /E7 mRNA can provide animportant clinical guidance for monitoring and prognosis of cervical disease.
