CAJ | 학술논문

目的：探索轻度血管性认知障碍（ MCI ）患者血清同型半胱氨酸（ HCY ）、超敏C反应蛋白（ hs-CRP）与颈动脉狭窄的关系。方法以我院2011年10月至2013年10月收入的98例轻度血管性认知障碍患者为研究对象，经颈部血管彩超诊断颈动脉狭窄的58例患者为观察组，同期住院的40例非认知障碍性脑血管病患者为对照组，两组进行HCY和hs-CRP水平测定。结果98例MCI患者颈动脉狭窄为59．18％，其中轻度狭窄为16．33％，中度狭窄为19．39％，重度狭窄为23．47％；有血流动力学改变的中重度狭窄为38．78％；无狭窄为40．82％。对照组40例患者，颈动脉狭窄为12．50％，其中轻度狭窄为10．00％，中度狭窄为2．50％，有血流动力学改变的为2．50％，各项检出指标观察组均显著高于对照组，其差异具有统计学意义，P＜0．05；轻、中、重度颈动脉狭窄患者的HCY、hs-CRP水平分别与对照组比较，差异均具有统计学意义，P＜0．05；HCY水平3组间比较，均为差异有统计学意义，P＜0．05；hs-CRP水平，轻度狭窄组与中度狭窄组相比差异无统计学意义P＞0．05，重度狭窄组与轻、中度狭窄组相比差异有统计学意义，P＜0．05。结论高HCY水平、高hs-CRP水平以及颈动脉狭窄与MCI密切相关，探究三者的相关性可为未来临床确定新的治疗靶点提供铺垫作用。
목적：탐색경도혈관성인지장애（ MCI ）환자혈청동형반광안산（ HCY ）、초민C반응단백（ hs-CRP）여경동맥협착적관계。방법이아원2011년10월지2013년10월수입적98례경도혈관성인지장애환자위연구대상，경경부혈관채초진단경동맥협착적58례환자위관찰조，동기주원적40례비인지장애성뇌혈관병환자위대조조，량조진행HCY화hs-CRP수평측정。결과98례MCI환자경동맥협착위59．18％，기중경도협착위16．33％，중도협착위19．39％，중도협착위23．47％；유혈류동역학개변적중중도협착위38．78％；무협착위40．82％。대조조40례환자，경동맥협착위12．50％，기중경도협착위10．00％，중도협착위2．50％，유혈류동역학개변적위2．50％，각항검출지표관찰조균현저고우대조조，기차이구유통계학의의，P＜0．05；경、중、중도경동맥협착환자적HCY、hs-CRP수평분별여대조조비교，차이균구유통계학의의，P＜0．05；HCY수평3조간비교，균위차이유통계학의의，P＜0．05；hs-CRP수평，경도협착조여중도협착조상비차이무통계학의의P＞0．05，중도협착조여경、중도협착조상비차이유통계학의의，P＜0．05。결론고HCY수평、고hs-CRP수평이급경동맥협착여MCI밀절상관，탐구삼자적상관성가위미래림상학정신적치료파점제공포점작용。
Objective To explore the mild vascular cognitive impairment ( MCI ) patients with serum homocysteine (HCY), Chao Min C reactive protein (hs-CRP) and carotid artery stenosis.Methods 98 cases of mild vascular cognitive impairment patients in our hospital in 2011 October ~2013 year in October income as the object of study , the diagnosis of 58 cases of neck vascular color Doppler ultrasound of carotid artery stenosis were treated as observation group , of 40 inpatients in patients without cognitive impairment of cerebral vascular disease as control group , two groups HCY and hs-CRP levels determination of .Results 98 cases of patients with carotid artery stenosis was 59.18% MCI, including mild stenosis 16.33%, moderate stenosis, severe stenosis were 19.39%, 23.47%;a hemodynamic changes in severe stenosis was 38.78;no stenosis was 40.82%.A control group of 40 patients, carotid artery stenosis was 12.50%, including mild stenosis 10%, moderate stenosis was 2.50%, with the hemodynamic changes of the detection index is 2.50%, the observation group were significantly higher than those in control group , the difference was significant , P<0.05;light, heavy, in the degree of carotid artery stenosis in patients with HCY the level of hs-CRP, respectively , compared with the control group , the differences were statistically significant , P<0.05;HCY levels between the 3 groups, are statistically significant differences, P<0.05; hs-CRP, mild stenosis group and the moderate stenosis group there was no significant difference of P >0.05, severe stenosis group and light , moderate stenosis group have significant difference compared, P<0.05.Conclusions High HCY level, high s-CRP levels and carotid artery stenosis is closely related with MCI , correlation between the three can provide a foreshadowing role for clinical determine the future of new therapeutic targets .