华南农业大学学报
華南農業大學學報
화남농업대학학보
JOURNAL OF SOUTH CHINA AGRICULTURAL UNIVERSITY
2013年
4期
553-557
,共5页
人参皂苷Rb3%降血糖%降血脂%抗氧化%小鼠
人參皂苷Rb3%降血糖%降血脂%抗氧化%小鼠
인삼조감Rb3%강혈당%강혈지%항양화%소서
ginsenoside Rb 3%antihyperglycemia%reduction of serum lipid%antioxidation%mice
为探讨人参皂苷Rb3对糖尿病治疗的作用及机理，以链脲佐菌素（ STZ）诱导的糖尿病小鼠模型为材料，系统分析了人参皂苷Rb3对糖尿病小鼠在降血糖、降血脂、胰岛素调节及抗氧化机能方面的作用．对小鼠禁食血糖浓度的测定显示，人参皂苷Rb3灌胃给药14 d后对糖尿病小鼠具有极显著的降血糖作用（P＜0.01），其中剂量为30 mg· kg-1的人参皂苷Rb3具有更好的降糖效果．人参皂苷Rb3的降糖效果与糖尿病治疗药物盐酸二甲双胍相近．对小鼠血清中总胆固醇（ TC）、三酰甘油（ TG）及胰岛素（ INS）的含量测定发现，人参皂苷Rb3在降低糖尿病小鼠的血脂浓度和提高胰岛素含量方面均具有显著的调节作用，其中剂量为30 mg· kg-1的人参皂苷Rb3具有更好的疗效，各项治疗指标均优于盐酸二甲双胍．对小鼠抗氧化机能的分析表明，人参皂苷Rb3在提高糖尿病小鼠血液中超氧化物歧化酶（ SOD）活力方面具有显著作用，同时可以有效降低糖尿病小鼠血清中丙二醛（ MDA）的含量，这对于改善糖尿病小鼠的抗氧化能力和缓解并发症的发生具有重要意义．
為探討人參皂苷Rb3對糖尿病治療的作用及機理，以鏈脲佐菌素（ STZ）誘導的糖尿病小鼠模型為材料，繫統分析瞭人參皂苷Rb3對糖尿病小鼠在降血糖、降血脂、胰島素調節及抗氧化機能方麵的作用．對小鼠禁食血糖濃度的測定顯示，人參皂苷Rb3灌胃給藥14 d後對糖尿病小鼠具有極顯著的降血糖作用（P＜0.01），其中劑量為30 mg· kg-1的人參皂苷Rb3具有更好的降糖效果．人參皂苷Rb3的降糖效果與糖尿病治療藥物鹽痠二甲雙胍相近．對小鼠血清中總膽固醇（ TC）、三酰甘油（ TG）及胰島素（ INS）的含量測定髮現，人參皂苷Rb3在降低糖尿病小鼠的血脂濃度和提高胰島素含量方麵均具有顯著的調節作用，其中劑量為30 mg· kg-1的人參皂苷Rb3具有更好的療效，各項治療指標均優于鹽痠二甲雙胍．對小鼠抗氧化機能的分析錶明，人參皂苷Rb3在提高糖尿病小鼠血液中超氧化物歧化酶（ SOD）活力方麵具有顯著作用，同時可以有效降低糖尿病小鼠血清中丙二醛（ MDA）的含量，這對于改善糖尿病小鼠的抗氧化能力和緩解併髮癥的髮生具有重要意義．
위탐토인삼조감Rb3대당뇨병치료적작용급궤리，이련뇨좌균소（ STZ）유도적당뇨병소서모형위재료，계통분석료인삼조감Rb3대당뇨병소서재강혈당、강혈지、이도소조절급항양화궤능방면적작용．대소서금식혈당농도적측정현시，인삼조감Rb3관위급약14 d후대당뇨병소서구유겁현저적강혈당작용（P＜0.01），기중제량위30 mg· kg-1적인삼조감Rb3구유경호적강당효과．인삼조감Rb3적강당효과여당뇨병치료약물염산이갑쌍고상근．대소서혈청중총담고순（ TC）、삼선감유（ TG）급이도소（ INS）적함량측정발현，인삼조감Rb3재강저당뇨병소서적혈지농도화제고이도소함량방면균구유현저적조절작용，기중제량위30 mg· kg-1적인삼조감Rb3구유경호적료효，각항치료지표균우우염산이갑쌍고．대소서항양화궤능적분석표명，인삼조감Rb3재제고당뇨병소서혈액중초양화물기화매（ SOD）활력방면구유현저작용，동시가이유효강저당뇨병소서혈청중병이철（ MDA）적함량，저대우개선당뇨병소서적항양화능력화완해병발증적발생구유중요의의．
In order to investigate the role of ginsenoside Rb 3 in the therapy of diabetes and its mecha-nisms, the streptozocin-induced diabetic mice model was constructed and the effects of ginsenoside Rb 3 on serum glucose , serum lipid , insulin and antioxidative indices were systematically studied .The detec-tion of fasting blood glucose levels indicated that 14 d treatment with ginsenoside Rb 3 via intragastric ad-ministration had a significant ( P<0 .01 ) hypoglycemic activity on diabetic mice and the concentration of 30 mg· kg -1 had more effective therapy results , which was equivalent to that of diabetic medicine met-formin hydrochloride .The effects of ginsenoside Rb 3 on serum total cholesterol ( TC ) , glycerin trimyr-istate ( TG) and insulin ( INS) were analyzed and the results showed that the Rb 3 had a significant regula-tory function to decrease the concentration of serum lipid , which increased that of insulin in diabetic mice.The dose of 30 mg· kg -1 Rb3 was more effective than that of metformin hydrochloride .The antiox-dative effects of Rb 3 were evaluated and the results illustrated that the activity of superoxide dismutase (SOD) had greatly increased, while the content of malonaldehyde (MDA) had obviously decreased in In order to investigate the role of ginsenoside Rb 3 in the therapy of diabetes and its mecha-nisms, the streptozocin-induced diabetic mice model was constructed and the effects of ginsenoside Rb 3 on serum glucose , serum lipid , insulin and antioxidative indices were systematically studied .The detec-tion of fasting blood glucose levels indicated that 14 d treatment with ginsenoside Rb 3 via intragastric ad-ministration had a significant ( P<0 .01 ) hypoglycemic activity on diabetic mice and the concentration of 30 mg· kg -1 had more effective therapy results , which was equivalent to that of diabetic medicine met-formin hydrochloride .The effects of ginsenoside Rb 3 on serum total cholesterol ( TC ) , glycerin trimyr-istate ( TG) and insulin ( INS) were analyzed and the results showed that the Rb 3 had a significant regula-tory function to decrease the concentration of serum lipid , which increased that of insulin in diabetic mice.The dose of 30 mg· kg -1 Rb3 was more effective than that of metformin hydrochloride .The antiox-dative effects of Rb 3 were evaluated and the results illustrated that the activity of superoxide dismutase (SOD) had greatly increased, while the content of malonaldehyde (MDA) had obviously decreased in diabetic mice after the treatment of Rb 3 , which was significant in improving the antioxdative ability and relieving diabetic complication .
