CAJ | 학술논문

为获得高效的海洋生物毒素河豚毒素（TTX）解毒剂，合成了一系列4-氨基吡啶类衍生物N-二异丙基磷酰化氨基酸-N-4-氨基吡啶；研究了N-二异丙基磷酰化氨基酸-N-4-氨基吡啶的多级质谱（ESI-M S/M S ）裂解方式；提出了碎片离子 m/z ＝95的裂解途径，并推测了其重排机理。结果表明，该类化合物具有相同分子量的碎片离子c/c′，是由两种母离子a或b离子裂解得到的。通过在吡啶环上引入氯原子可证实该裂解途径；而碎片离子 m/z ＝95源于离子重排。
위획득고효적해양생물독소하돈독소（TTX）해독제，합성료일계렬4-안기필정류연생물N-이이병기린선화안기산-N-4-안기필정；연구료N-이이병기린선화안기산-N-4-안기필정적다급질보（ESI-M S/M S ）렬해방식；제출료쇄편리자 m/z ＝95적렬해도경，병추측료기중배궤리。결과표명，해류화합물구유상동분자량적쇄편리자c/c′，시유량충모리자a혹b리자렬해득도적。통과재필정배상인입록원자가증실해렬해도경；이쇄편리자 m/z ＝95원우리자중배。
A series of novel 4-aminopyridine derivatives containing N-diisopropyloxyphosphoryl amino acid unit were synthesized as highly efficient antidotes of tetradotoxin ,a marine organ-ism toxin . The fragmentation pathway of as-synthesized N-diisopropyloxyphosphoryl amino acid-N-4-aminopyridines was investigated by means of positive ion electrospray ionization mass spectrometry (ESI-MS) in conjunction with tandem mass spectrometry (MS/MS) .Moreover , the fragmentation pathway of fragment ion m/z = 95 was proposed ,and its possible rearrange-ment mechanism was supposed .Results indicate all that the compounds under investigation have fragment ion c/c′with the same molecular weight ,and fragment ion c/c′is derived from precursor ions a and b .Such a fragmentation pathway can be verified by introducing tracer ele-ment Cl onto the pyridine ring of the title derivatives ,while the fragment ion m/z = 95 is generated by way of ion rearrangement .