CAJ | 학술논문

目的：探讨初治鼻咽癌患者调强适形放疗的疗效及预后因素分析。方法选取我院2008年1月~2011年3月收治的288例初治鼻咽癌患者做为研究对象。按照入院顺序随机分为治疗组145例与对照组143例，治疗组患者应用调强适形技术放疗治疗（intensity modulated radiation therapy，IMRT），对照组患者应用3DCRT放疗方法治疗。对比两组患者的临床放疗效果及预后情况。结果治疗组患者的放疗效果显著优于对照组，差异有统计学意义（P＜0.05）。治疗组患者的急性放射性损伤（放射性口干、黏膜炎、骨髓抑制、皮肤反应）Ⅲ级~Ⅳ级发生率低于对照组患者，差异有统计学意义（P＜0.05）。结论给予初治鼻咽癌患者调强适形放疗方法放疗，临床效果显著，正常重要器官与组织损伤小，无重度不良反应，临床值得广泛推广应用。
목적：탐토초치비인암환자조강괄형방료적료효급예후인소분석。방법선취아원2008년1월~2011년3월수치적288례초치비인암환자주위연구대상。안조입원순서수궤분위치료조145례여대조조143례，치료조환자응용조강괄형기술방료치료（intensity modulated radiation therapy，IMRT），대조조환자응용3DCRT방료방법치료。대비량조환자적림상방료효과급예후정황。결과치료조환자적방료효과현저우우대조조，차이유통계학의의（P＜0.05）。치료조환자적급성방사성손상（방사성구간、점막염、골수억제、피부반응）Ⅲ급~Ⅳ급발생솔저우대조조환자，차이유통계학의의（P＜0.05）。결론급여초치비인암환자조강괄형방료방법방료，림상효과현저，정상중요기관여조직손상소，무중도불량반응，림상치득엄범추엄응용。
Objective To explore and analyze the curative effect and prognosis of intensity modulated radiation therapy(IMRT) in the initial treatment of nasopharyngeal carcinoma. Methods 288 patients with nasopharyngeal carcinoma who were admitted to our hospital and initially treated from January 2008 to March 2011 were selected as research subjects. They were randomly allocated to a treatment group of 145 patients and a control group of 143 patients according to admission order. The treatment group received IMRT, while the control group received 3D-CRT. Clinical effects of radiotherapy and prognosis were compared between the two groups. Results The effects of radiotherapy in the treatment group were significantly better than those in the control group, and the difference was statistically significant(P<0.05). Incidence of levelⅢto levelⅣacute radiation damages(radioactive xerostomia, mucositis, myelosuppression and skin reactions) in the treatment group was lower than that in the control group, and the difference was statistically significant(P<0.05). Conclusion IMRT in the initial treatment of nasopharyngeal carcinoma has a significant clinical effect with minor damages to key organs and tissues, and without severe adverse events, which is worthy of widespread clinical promotion and application.