CAJ | 학술논문

目的：探讨安宝联合硫酸镁治疗接近足月的PPROM的临床疗效与安全性。方法选取2010年9月～2013年5月来我院就诊的孕32～33+6周胎膜早破孕妇120例，将所选病例随机分为联合治疗组、安宝组以及硫酸镁组。经治疗后，分别观察记录三组病例的治疗时间、宫缩抑制时间、妊娠延长时间、不良反应及临床疗效。结果安宝组与联合治疗组的治疗时间、宫缩抑制时间、妊娠延长时间差异不明显，但是硫酸镁组与联合治疗组相比，联合治疗组的治疗时间、宫缩抑制时间有显著缩短，妊娠延长时间明显延长。三组治疗总有效率分别为安宝组85.0%，硫酸镁组65.0%，联合治疗组87.5%。安宝组与联合治疗组的总有效率差异不明显，但是硫酸镁组与联合治疗组相比，联合治疗组的总有效率明显高于硫酸镁组。硫酸镁组在治疗过程不良反应率为5.0%，安宝组不良反应率为15.0%，联合治疗组出不良反应率为7.5%，硫酸镁组与联合治疗组两组差异不显著；而安宝组和联合治疗组差异显著。结论安宝联合硫酸镁治疗未足月胎膜早破起效快，效果显著，不良反应少。
목적：탐토안보연합류산미치료접근족월적PPROM적림상료효여안전성。방법선취2010년9월～2013년5월래아원취진적잉32～33+6주태막조파잉부120례，장소선병례수궤분위연합치료조、안보조이급류산미조。경치료후，분별관찰기록삼조병례적치료시간、궁축억제시간、임신연장시간、불량반응급림상료효。결과안보조여연합치료조적치료시간、궁축억제시간、임신연장시간차이불명현，단시류산미조여연합치료조상비，연합치료조적치료시간、궁축억제시간유현저축단，임신연장시간명현연장。삼조치료총유효솔분별위안보조85.0%，류산미조65.0%，연합치료조87.5%。안보조여연합치료조적총유효솔차이불명현，단시류산미조여연합치료조상비，연합치료조적총유효솔명현고우류산미조。류산미조재치료과정불량반응솔위5.0%，안보조불량반응솔위15.0%，연합치료조출불량반응솔위7.5%，류산미조여연합치료조량조차이불현저；이안보조화연합치료조차이현저。결론안보연합류산미치료미족월태막조파기효쾌，효과현저，불량반응소。
Objective To investigate the efficacy and safety of amber combined with magnesium sulfate in the treatment of near-term preterm premature rupture of membranes(PPROM). Methods 120 PPROM pregnant women cases with 32 to 33+6 weeks pregnancy were selected from September 2010 to May 2013 in our hospital. According to the random number table, they were divided into the combined treatment group, magnesium sulfate group and amber group. The contraction inhibition time, treatment time, gestational age extension time, adverse reaction and clinical efficacy were observed. Results Inhibition time, treatment time and gestational age extension time were not significantly different in combined treatment group and amber group, but inhibition time, treatment time and gestational ages extension time were significantly different in the combined treatment group and Magnesium Sulfate group. The total effective rates of three groups were 85.0%in amber group, 65.0%in magnesium group and 87.5%in combined treatment group. The total efficiency rate of the combined treatment group was significantly higher than the magnesium sulfate group, while amber group showed no significant difference between the combined treatment group and Magnesium Sulfate group. During the treatment, adverse reactions rates were 5.0% in magnesium sulfate group, 15.0% in amber group and 7.5% in the combined treatment group. Magnesium group and the combined treatment group difference were not significant in adverse reactions rates;while amber group and combined treatment group were significantly different. Conclusion Amber group combined with magnesium sulfate on PPROM can significantly improve the efficacy, with rapid onset, and has little adverse reactions.