CAJ | 학술논문

目的：探讨阿托伐他汀和厄贝沙坦联合治疗原发性高血压的效果观察。方法选用2011年9月~2013年9月期间我院治疗原发性高血压的患者156例，随机分成两组，治疗组给予阿托伐他汀联合厄贝沙坦用药法，对照组给予厄贝沙坦单独用药法。对两组患者治疗前后各项心功能指标、临床疗效以及不良反应进行比较。结果两组患者治疗前心功能各项指标无明显差异（P＞0.05）；治疗后治疗组无论是心功能各项指标，还是临床疗效均显著优于对照组（P＜0.05），两组患者不良反应无明显差异（P＞0.05）。结论阿托伐他汀联合厄贝沙坦治疗原发性高血压，不但临床疗效十分显著，对于心脏功能亦有提升的效果，并且无不良反应现象发生，安全有效，值得临床中推广。
목적：탐토아탁벌타정화액패사탄연합치료원발성고혈압적효과관찰。방법선용2011년9월~2013년9월기간아원치료원발성고혈압적환자156례，수궤분성량조，치료조급여아탁벌타정연합액패사탄용약법，대조조급여액패사탄단독용약법。대량조환자치료전후각항심공능지표、림상료효이급불량반응진행비교。결과량조환자치료전심공능각항지표무명현차이（P＞0.05）；치료후치료조무론시심공능각항지표，환시림상료효균현저우우대조조（P＜0.05），량조환자불량반응무명현차이（P＞0.05）。결론아탁벌타정연합액패사탄치료원발성고혈압，불단림상료효십분현저，대우심장공능역유제승적효과，병차무불량반응현상발생，안전유효，치득림상중추엄。
Objective To investigate and explore the efficacy of atorvastatin combined with irbesartan in the treatment of essential hypertension. Methods 156 patients with essential hypertension who were admitted to our hospital from September 2011 to September 2013 were selected and randomly allocated to two groups. The treatment group was given atorvastatin combined with irbesartan,and the control group received irbesartan alone.Indices of heart function,clinical efficacy and adverse effects before and after the treatment in the two groups were compared. Results The differences of indices of heart function before the treatment in the two groups were not statistically significant(P>0.05).Indices of heart function and clinical efficacy in the treatment group after the treatment were all significantly better than those in the control group(P < 0.05).The differences of adverse effects between the two groups were not statistically significant(P>0.05). Conclusion Atorvastatin combined with irbesartan in the treatment of essential hypertension has a significant clinical efficacy,enhances heart functions and has no adverse effects,which is safe,effective and worthy of clinical promotion and application.