CAJ | 학술논문

鲍曼不动杆菌已成为21世纪临床重要致病菌之一。鲍曼不动杆菌的耐药机制复杂，尤其是XDRAB和PDRAB，常对多种抗生素耐药，临床上治疗较困难，而且病死率高。目前最重要的是要合理选用抗生素，以减轻抗生素的选择性压力，避免多重耐药菌株的出现，控制耐药菌株的传播，同时监测各个地区间细菌的耐药性分析指导经验性治疗用药，对耐药菌的耐药机制做进一步深入研究。此文对近年来国内外多重耐药鲍曼不动杆菌的耐药机制、临床治疗策略及最新研究等方面作一综述。
포만불동간균이성위21세기림상중요치병균지일。포만불동간균적내약궤제복잡，우기시XDRAB화PDRAB，상대다충항생소내약，림상상치료교곤난，이차병사솔고。목전최중요적시요합리선용항생소，이감경항생소적선택성압력，피면다중내약균주적출현，공제내약균주적전파，동시감측각개지구간세균적내약성분석지도경험성치료용약，대내약균적내약궤제주진일보심입연구。차문대근년래국내외다중내약포만불동간균적내약궤제、림상치료책략급최신연구등방면작일종술。
Acinetobacter baumannii has become one of the most important pathogens in clinical settings in the 21st century.The bacteria has a complex drug-resistant mechanisms. XDRAB and PDRAB,in particular,are resistant to a wide range of antibiotics.Clinical treatment to the bacteria is relatively difficult and related mortality rate remains high.The most important procedure is to properly select antibiotics so as to reduce selective pressure induced by antibiotics, avoid the occurrence of multi-drug resistant bacteria, and control the transmission of drug-resistant bacteria.At the same time,drug resistance of bacteria in different regions should be monitored,use of drugs in treatment should be analyzed and guided based on experience, and further researches should be carried out in terms of drug-resistant mechanisms of certain bacteria.This article provides an overview of drug-resistant mechanisms,clinical treatment strategy and latest researches of multi-drug resistant acinetobacter baumannii at home and abroad in recent years.