CAJ | 학술논문

近年随着肿瘤的高发磷脂酶A2（phospholipase A2，PLA2）逐渐引起人们的广泛关注，越来越多的研究表明PLA2是一个与肿瘤发生密切相关的炎症因子，其生物学变异小，特异性高，很少受其他炎症标志物影响，与多种肿瘤的发生相关。特别与消化道肿瘤中的肠癌和胃癌分化程度有一定关系，并与其侵袭转移机制及凋亡发生有关联。另外可协助生殖系统中的前列腺癌Gleason评分和临床药物治疗，以及与卵巢癌的增殖浸润密切相关，故磷脂酶A2可能作为临床诊治肿瘤新的检测指标，可能成为预测肿瘤发生及发展的一个新的研究方向。磷脂酶A2的生物学特性使其应用于临床实验室检测，将有助于肿瘤患者早期监测及制定个体化治疗方案。
근년수착종류적고발린지매A2（phospholipase A2，PLA2）축점인기인문적엄범관주，월래월다적연구표명PLA2시일개여종류발생밀절상관적염증인자，기생물학변이소，특이성고，흔소수기타염증표지물영향，여다충종류적발생상관。특별여소화도종류중적장암화위암분화정도유일정관계，병여기침습전이궤제급조망발생유관련。령외가협조생식계통중적전렬선암Gleason평분화림상약물치료，이급여란소암적증식침윤밀절상관，고린지매A2가능작위림상진치종류신적검측지표，가능성위예측종류발생급발전적일개신적연구방향。린지매A2적생물학특성사기응용우림상실험실검측，장유조우종류환자조기감측급제정개체화치료방안。
Phospholipase A2 (PLA2) has been a recent concern given the high incidence of tumors. Increasing amounts of re-search report that PLA2 is an inflammatory factor that is closely associated with tumor incidence. Moreover, it displays high specificity, minimal biological variation, is rarely affected by other inflammation markers, and has a definite relation with the differentiation in tu-mors of the digestive tract, such as intestinal and gastric cancers. PLA2 is also related to the invasion mechanisms, metastasis, and apop-tosis of tumors. In addition, PLA2 can be applied to the scoring and to the clinical and medicinal treatment of the Gleason tumor, which is found in prostatic cancers of the genital system. It is also closely related to the proliferation and infiltration of ovarian cancer cells. Therefore, PLA2 can be used as a new test index for the clinical diagnosis and treatment of tumors, which may generate a new research direction with respect to the forecasting of tumor incidence and progression. The bionomics of PLA2 facilitate the use of inflammatory factors in the detection procedures utilized by clinical laboratories, which can monitor the conditions of cancer patients in advance and effectively customize treatment regimens for such patients.