CAJ | 학술논문

含Src同源区2蛋白质酪氨酸磷酸酶（Src homology 2 domain containing protein tyrosine phosphatases，SHP2）是一种跨膜型蛋白酪氨酸磷酸酶，通过调节细胞内蛋白质的酪氨酸磷酸化水平，在细胞信号转导通路及控制细胞活性中发挥重要的作用。其活化状态与乳腺癌发生发展过程中的Ras/ERK，PI3K/Akt/mTOR等信号通路、激素水平、侵袭转移、肿瘤干细胞的生物学行为等密切相关。SHP2基因的敲除或抑制SHP2蛋白表达，可不同程度阻断与乳腺癌侵袭、转移相关的信号通路，从而抑制肿瘤生长，甚至不可逆地使肿瘤丧失重新获得干细胞特性的能力。因此，SHP2很可能为抗肿瘤药物的研发提供一个新的靶点。本文就SHP2与乳腺癌侵袭转移的相关研究进展进行综述。
함Src동원구2단백질락안산린산매（Src homology 2 domain containing protein tyrosine phosphatases，SHP2）시일충과막형단백락안산린산매，통과조절세포내단백질적락안산린산화수평，재세포신호전도통로급공제세포활성중발휘중요적작용。기활화상태여유선암발생발전과정중적Ras/ERK，PI3K/Akt/mTOR등신호통로、격소수평、침습전이、종류간세포적생물학행위등밀절상관。SHP2기인적고제혹억제SHP2단백표체，가불동정도조단여유선암침습、전이상관적신호통로，종이억제종류생장，심지불가역지사종류상실중신획득간세포특성적능력。인차，SHP2흔가능위항종류약물적연발제공일개신적파점。본문취SHP2여유선암침습전이적상관연구진전진행종술。
Src homology 2 domain-containing phosphatase (SHP2), which is encoded by proto-oncogene PTPN11, is one of the transmembrane protein-tyrosine phosphatases. SHP2 has an important function in signal transduction pathways and activities of cells through the regulation of tyrosine phosphorylation level of intracellular proteins. The status of SHP2 activation is closely connected with the regulation of hormone levels, state of invasion and metastasis of tumor, development and progression of tumor stem cells of breast cancer, as well as signal pathways including Ras/ERK and PI3K/Akt/mTOR. Gene knockout or gene silencing expression helps inhibit tumor growth, irreversibly hindering the ability of the tumor to regain stem cells and disturb the signal pathways of the invasion and metastasis of breast cancer. Recent studies have shown that SHP2 may help in bringing anticancer drugs to a higher level. This arti-cle concentrates on the research progress in relationship of SHP2 with invasion and metastasis of breast cancer.