CAJ | 학술논문

目的：观察法舒地尔治疗慢性阻塞性肺疾病急性加重期伴肺动脉高压患者的临床疗效。方法将70例慢性阻塞性肺疾病急性加重期伴肺动脉高压患者遵循随机数字表格法分为对照组35例，接受常规治疗，观察组35例，在常规治疗的基础上接受法舒地尔治疗，疗程为2周。记录并比较两组患者治疗前后的肺动脉收缩压、健康生活质量评分以及6 min步行试验(6-MWT)。结果治疗2周后，观察组患者的肺动脉收缩压与治疗前相比明显降低，6-MWT明显上升，此外，观察组患者在治疗后的健康生活质量评分显著高于治疗前，且差异均具有统计学意义(P<0.05)；治疗后两组患者6-MWT均有所升高，但观察组明显优于对照组，两组患者在治疗后的肺动脉收缩压均明显下降，但观察组的下降幅度要高于对照组，其差异均有统计学意义(P<0.05)；两组的健康生活质量评分比较，在精神健康及精力方面比较差异有统计学意义(P<0.05)，其他指标则差异无统计学意义(P>0.05)。结论法舒地尔治疗慢性阻塞性肺疾病急性加重期伴肺动脉高压效果良好，值得临床推广使用。
목적：관찰법서지이치료만성조새성폐질병급성가중기반폐동맥고압환자적림상료효。방법장70례만성조새성폐질병급성가중기반폐동맥고압환자준순수궤수자표격법분위대조조35례，접수상규치료，관찰조35례，재상규치료적기출상접수법서지이치료，료정위2주。기록병비교량조환자치료전후적폐동맥수축압、건강생활질량평분이급6 min보행시험(6-MWT)。결과치료2주후，관찰조환자적폐동맥수축압여치료전상비명현강저，6-MWT명현상승，차외，관찰조환자재치료후적건강생활질량평분현저고우치료전，차차이균구유통계학의의(P<0.05)；치료후량조환자6-MWT균유소승고，단관찰조명현우우대조조，량조환자재치료후적폐동맥수축압균명현하강，단관찰조적하강폭도요고우대조조，기차이균유통계학의의(P<0.05)；량조적건강생활질량평분비교，재정신건강급정력방면비교차이유통계학의의(P<0.05)，기타지표칙차이무통계학의의(P>0.05)。결론법서지이치료만성조새성폐질병급성가중기반폐동맥고압효과량호，치득림상추엄사용。
Objective To observe the clinical curative effect of fasudil hydrochloride in treatment of pa-tients with acute exacerbation of chronic obstructive pulmonary disease accompany by pulmonary hypertension. Methods By using a random number table, 70 cases were divided into a control group with 35 patients who received conventional treatment, and an observation group with 35 cases who accepted fasudil treatment on the basis of conven-tional therapy. All patients were treated for two weeks. Healthy quality of life score, pulmonary artery systolic pressure, and six-minute walk test (6-MWT) results before and after treatment were recorded and analyzed. Results After 2 weeks of treatment, compared with those before treatment, the observation group showed a decrease in pulmonary arte-rial systolic pressure and an increase in 6-MWT and healthy quality of life scores with statistical differences (P<0.05). After treatment, 6-MWT increased in both groups, but the increasing in the observation group was greater than that in the control group. The pulmonary artery systolic pressure decreased in both groups, but the decrease in the observa-tion group was greater, with a statistical difference (P<0.05). As to healthy quality of life scores, there were differ-ences in energy, mental health indexes between the two groups (P<0.05), and there was no difference in other indexes (P>0.05). Conclusion Fasudil shows good effects on the treatment of patients with acute exacerbation of chronic ob-structive pulmonary disease accompany by pulmonary hypertension. Therefore, it is worthy of clinical use.