中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
20期
41-43
,共3页
法舒地尔%急性心肌梗死%心力衰竭
法舒地爾%急性心肌梗死%心力衰竭
법서지이%급성심기경사%심력쇠갈
Fasudil%Acute myocardial infarction%Heart failure
目的：观察法舒地尔对急性心肌梗死合并心力衰竭患者心脏功能的影响。方法：选取2011年1月-2013年10月在本院住院的80例急性心肌梗死合并心力衰竭患者，按照随机数字表法将其分为治疗组和对照组各40例，连续治疗15 d，观察治疗前后两组患者的左室收缩末期内径（LVESV）、左室舒张末期内径（LVEDV）、左室射血分数（LVEF）及血清NT-proBNP含量。结果：经治疗后两组LVESD、LVEDD和血清NT-proBNP均有不同程度减少（P<0.05或P<0.01），与对照组相比，治疗组的LVESD、LVEDD和血清NT-proBNP均减少更加明显，差异均有统计学意义（P<0.01）；两组治疗后的LVEF较治疗前均有不同程度提高，与对照组相比，治疗组的LVEF提高更加显著，差异均有统计学意义（P<0.01）。结论：法舒地尔在治疗急性心肌梗死合并心力衰竭上有一定疗效，可以改善左室结构及射血分数，值得临床推广应用。
目的：觀察法舒地爾對急性心肌梗死閤併心力衰竭患者心髒功能的影響。方法：選取2011年1月-2013年10月在本院住院的80例急性心肌梗死閤併心力衰竭患者，按照隨機數字錶法將其分為治療組和對照組各40例，連續治療15 d，觀察治療前後兩組患者的左室收縮末期內徑（LVESV）、左室舒張末期內徑（LVEDV）、左室射血分數（LVEF）及血清NT-proBNP含量。結果：經治療後兩組LVESD、LVEDD和血清NT-proBNP均有不同程度減少（P<0.05或P<0.01），與對照組相比，治療組的LVESD、LVEDD和血清NT-proBNP均減少更加明顯，差異均有統計學意義（P<0.01）；兩組治療後的LVEF較治療前均有不同程度提高，與對照組相比，治療組的LVEF提高更加顯著，差異均有統計學意義（P<0.01）。結論：法舒地爾在治療急性心肌梗死閤併心力衰竭上有一定療效，可以改善左室結構及射血分數，值得臨床推廣應用。
목적：관찰법서지이대급성심기경사합병심력쇠갈환자심장공능적영향。방법：선취2011년1월-2013년10월재본원주원적80례급성심기경사합병심력쇠갈환자，안조수궤수자표법장기분위치료조화대조조각40례，련속치료15 d，관찰치료전후량조환자적좌실수축말기내경（LVESV）、좌실서장말기내경（LVEDV）、좌실사혈분수（LVEF）급혈청NT-proBNP함량。결과：경치료후량조LVESD、LVEDD화혈청NT-proBNP균유불동정도감소（P<0.05혹P<0.01），여대조조상비，치료조적LVESD、LVEDD화혈청NT-proBNP균감소경가명현，차이균유통계학의의（P<0.01）；량조치료후적LVEF교치료전균유불동정도제고，여대조조상비，치료조적LVEF제고경가현저，차이균유통계학의의（P<0.01）。결론：법서지이재치료급성심기경사합병심력쇠갈상유일정료효，가이개선좌실결구급사혈분수，치득림상추엄응용。
To observe the cardiac function effect of fasudil on acute myocardial infarction complicated with heart failure.Method:80 cases of acute myocardial infarction complicated with heart failure who hospitalized in our hospital from January 2011 to October 2013 were selected,they were randomly divided into the treatment group and the control group according to the random number table method,40 cases in each group.Continuous treatment for 15 d,the changes of left ventricle end-systolic dimension(LVESD),left ventricle end-diastolic dimension(LVEDD),left ventricle ejection fraction(LVEF)and the level of NT-proBNP between the two groups before and after treatment were observed and compared.Result:After treatment,LVESD,LVEDD and the level of NT-proBNP of the two groups were decreased in different degree(P<0.05 or P<0.01),compared with the control group,LVESD,LVEDD and the level of NT-proBNP in the treatment group were decreased more significantly,the differences were statistically significant (P<0.01).Compared with before treatment,the LVEF of the two groups after treatment were improved in different degree,compared with the control group,the LVEF of the treatment group were improved more significantly,the differences were statistically significant(P<0.01).Conclusion:Fasudil has a certain therapeutic effect in the treatment of acute myocardial infarction complicated with heart failure,improve left ventricular hypertrophy and left ventricular ejection fraction,is worthy of clinical application.
