中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
20期
15-17
,共3页
胱抑素C%2型糖尿病%慢性并发症
胱抑素C%2型糖尿病%慢性併髮癥
광억소C%2형당뇨병%만성병발증
Cystatin C%Type 2 diabetes mellitus%Chronic complications
目的:探讨血清胱抑素C(CysC)与2型糖尿病(T2DM)慢性并发症的相关性。方法:510例T2DM患者根据是否合并T2DM慢性并发症分为无合并糖尿病并发症的糖尿病对照组(NC组),合并周围血管病变(PAD)组、合并肾脏病变(DN)组、合并视网膜病变(DR)组,合并周围神经病变(DPN)组,记录患者的年龄、病程、身高、体重、腰围、臀围,测定空腹血糖(FBG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹胰岛素(FINS)、CysC、血肌酐(Scr)、肾小球率过滤(GFR)等相关指标,计算体重指数(BMI)、腰臀比(WHR)、胰岛素抵抗指数(HOMA-IR),比较各组间所测指标的差异性,并分析CysC与各指标的相关性。结果:2型糖尿病合并PAD、DN、DR以及DPN组的血清Cys C水平均高于不合并糖尿病并发症的糖尿病对照组(NC组)(P<0.05)。结论:血清Cys C升高可作为提示糖尿病周围血管病变、肾脏病变、视网膜病变、周围周围神经病变危险性增加的参考指标,并可能是T2DM患者慢性并发症的独立危险因素。
目的:探討血清胱抑素C(CysC)與2型糖尿病(T2DM)慢性併髮癥的相關性。方法:510例T2DM患者根據是否閤併T2DM慢性併髮癥分為無閤併糖尿病併髮癥的糖尿病對照組(NC組),閤併週圍血管病變(PAD)組、閤併腎髒病變(DN)組、閤併視網膜病變(DR)組,閤併週圍神經病變(DPN)組,記錄患者的年齡、病程、身高、體重、腰圍、臀圍,測定空腹血糖(FBG)、糖化血紅蛋白(HbA1c)、總膽固醇(TC)、甘油三酯(TG)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)、空腹胰島素(FINS)、CysC、血肌酐(Scr)、腎小毬率過濾(GFR)等相關指標,計算體重指數(BMI)、腰臀比(WHR)、胰島素牴抗指數(HOMA-IR),比較各組間所測指標的差異性,併分析CysC與各指標的相關性。結果:2型糖尿病閤併PAD、DN、DR以及DPN組的血清Cys C水平均高于不閤併糖尿病併髮癥的糖尿病對照組(NC組)(P<0.05)。結論:血清Cys C升高可作為提示糖尿病週圍血管病變、腎髒病變、視網膜病變、週圍週圍神經病變危險性增加的參攷指標,併可能是T2DM患者慢性併髮癥的獨立危險因素。
목적:탐토혈청광억소C(CysC)여2형당뇨병(T2DM)만성병발증적상관성。방법:510례T2DM환자근거시부합병T2DM만성병발증분위무합병당뇨병병발증적당뇨병대조조(NC조),합병주위혈관병변(PAD)조、합병신장병변(DN)조、합병시망막병변(DR)조,합병주위신경병변(DPN)조,기록환자적년령、병정、신고、체중、요위、둔위,측정공복혈당(FBG)、당화혈홍단백(HbA1c)、총담고순(TC)、감유삼지(TG)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)、공복이도소(FINS)、CysC、혈기항(Scr)、신소구솔과려(GFR)등상관지표,계산체중지수(BMI)、요둔비(WHR)、이도소저항지수(HOMA-IR),비교각조간소측지표적차이성,병분석CysC여각지표적상관성。결과:2형당뇨병합병PAD、DN、DR이급DPN조적혈청Cys C수평균고우불합병당뇨병병발증적당뇨병대조조(NC조)(P<0.05)。결론:혈청Cys C승고가작위제시당뇨병주위혈관병변、신장병변、시망막병변、주위주위신경병변위험성증가적삼고지표,병가능시T2DM환자만성병발증적독립위험인소。
To investigate the correlation between serum cystatin C(CysC)and chronic complications in type 2 diabetes(T2DM). Method:Based on T2DM chronic complications situation,510 cases of patients with T2DM were divided into no complications(NC)group,peripheral artery disease(PAD)group,kidney disease(DN) group,retinopathy(DR)group,and peripheral neuropathy(DPN)group.The related indicators included patient's age, disease course,height,weight,waist circumference,hip circumference,fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),fasting insulin(FINS),CysC,serum creatinine(Scr),glomerular filtration rate(GFR)were recorded.And body mass index(BMI),waist hip ratio(WHR),and insulin resistance index(HOMA IR)were calculated.The difference between indicators was compared,and correlation between CysC and indicators were analyzed.Result:Cys C level of PAD,DN,DR,and DPN group were significantly higher than that of NC group(P<0.05). Conclusion:The increase of serum Cys C can be used as risk indicators of peripheral artery disease,kidney disease, retinopathy,and peripheral neuropathy.Serum Cys C may be independent risk factors of T2DM patients with chronic complications.