CAJ | 학술논문

目的：观察美沙拉嗪联合益生菌对炎症性肠病大鼠血清中L-6、TNF-α和IFN-γ含量的影响，并初步探讨该方法治疗炎症性肠病的作用机制。方法：将40只雄性SD大鼠随机分为四组，即正常对照组、模型组、美沙拉嗪组和美沙拉嗪益生菌联合组，最后各组大鼠取血，应用ELISA法检测血清中IL-6、TNF-α和IFN-γ含量。结果：美沙拉嗪联合益生菌组IL-6、TNF-α和IFN-γ含量的表达均明显低于模型组（P<0.05）。结论：美沙拉嗪联合益生菌在缓解肠道炎症中发挥着重要作用。
목적：관찰미사랍진연합익생균대염증성장병대서혈청중L-6、TNF-α화IFN-γ함량적영향，병초보탐토해방법치료염증성장병적작용궤제。방법：장40지웅성SD대서수궤분위사조，즉정상대조조、모형조、미사랍진조화미사랍진익생균연합조，최후각조대서취혈，응용ELISA법검측혈청중IL-6、TNF-α화IFN-γ함량。결과：미사랍진연합익생균조IL-6、TNF-α화IFN-γ함량적표체균명현저우모형조（P<0.05）。결론：미사랍진연합익생균재완해장도염증중발휘착중요작용。
To observe the effect of combined treatment of Mesalamine and Probiotics in IL-6, TNF-α and IFN-γ of the rats with Inflammatory bowel disease,and to explore the mechanism of the treatment for inflammatory bowel disease.Method:40 male SD rats were randomly divided into four groups,namely normal control group,model group,Mesalamine group and the combined group.IL-6,TNF-αand IFN-γin the serum of rats were detected by ELISA method.Result:The expression of IL-6,TNF-αand IFN-γin the combined group were significantly lower than those in the model group(P<0.05).Conclusion:The combined treatment of Mesalamine and Probiotics plays an important role in alleviating intestinal inflamm.