CAJ | 학술논문

目的：探讨布地奈德与复方异丙托溴铵联合雾化吸入治疗慢性阻塞性肺疾病急性加重期的疗效。方法：将80例AECOPD患者按照随机数字表法分为治疗组和对照组各40例，两组均给予基础治疗，治疗组加用布地奈德与复方异丙托溴铵联合雾化吸入，对照组加用硫酸沙丁胺醇雾化吸入，观察比较两组患者的临床疗效、治疗前后呼吸困难评分、动脉血气指标及肺功能指标的变化情况、患者症状、体征缓解时间及不良反应情况。结果：治疗10 d后，治疗组总有效率95.0%明显高于对照组的75.0%，且治疗组治疗后的呼吸困难评分、PaO2及PaCO2等动脉血气指标、FEV1/FVC、FEV占预计值百分比等肺功能指标的改善程度均明显优于对照组，且两组治疗后的上述指标均明显优于治疗前，治疗组的咳嗽缓解时间、气促、喘息、肺部体征消失时间均明显短于对照组，差异均有统计学意义（P<0.05）。结论：布地奈德与复方异丙托溴铵联合雾化吸入治疗慢性阻塞性肺疾病急性加重期疗效确切，缓解病情的速度较快，值得临床推广应用。
목적：탐토포지내덕여복방이병탁추안연합무화흡입치료만성조새성폐질병급성가중기적료효。방법：장80례AECOPD환자안조수궤수자표법분위치료조화대조조각40례，량조균급여기출치료，치료조가용포지내덕여복방이병탁추안연합무화흡입，대조조가용류산사정알순무화흡입，관찰비교량조환자적림상료효、치료전후호흡곤난평분、동맥혈기지표급폐공능지표적변화정황、환자증상、체정완해시간급불량반응정황。결과：치료10 d후，치료조총유효솔95.0%명현고우대조조적75.0%，차치료조치료후적호흡곤난평분、PaO2급PaCO2등동맥혈기지표、FEV1/FVC、FEV점예계치백분비등폐공능지표적개선정도균명현우우대조조，차량조치료후적상술지표균명현우우치료전，치료조적해수완해시간、기촉、천식、폐부체정소실시간균명현단우대조조，차이균유통계학의의（P<0.05）。결론：포지내덕여복방이병탁추안연합무화흡입치료만성조새성폐질병급성가중기료효학절，완해병정적속도교쾌，치득림상추엄응용。
To investigate the efficacy of inhalation of budesonide and compound ipratropium bromide aerosol in treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Method:80 patients with AECOPD were randomly divided into the treatment group and the control group,40 cases in each group.The two groups were given basic treatment.The treatment group was given inhalation of budesonide and compound ipratropium bromide aerosol,and the control group was given salbutamol sulfate.The clinical curative effect,dyspnea score and changes of arterial blood gas indexes and lung function indexes before and after the treatment,the symptoms,signs of remission time and adverse reactions between the two groups were observed and compared.Result:After 10 days treatment,the total effective rate of the treatment group was 95.0%,it was significantly higher than 75.0%of the control group,and the improvements of dyspnea score,arterial blood gas indices such as PaO2 and PaCO2,lung function indices such as FEV1/FVC and PreFEV%of treatment group were significantly better than those of the control group,the index of the two groups after treatment were significantly better than before treatment,and the cough,shortness of breath, wheezing relief time,pulmonary symptoms disappear time in the treatment group were significantly shorter than the control group,the differences were statistically significant(P<0.05).Conclusion:The efficacy of inhalation of budesonide and compound ipratropium bromide aerosol in treatment of AECOPD is certain,and it is worthy of clinical application.