CAJ | 학술논문

目的：探讨混合性血管内皮瘤临床病例特点、免疫组化表型及以往文献回顾复习。方法对1例前臂混合性血管内皮瘤病例组织病理学观察及检验免疫组化表型中的CD31、CD34、第Ⅷ因子、D2-40、EMA、Vimentin、Ki67等指标的表达。结果巨检院送检肿物为带梭形皮瓣组织，肿物4.5 cm×3 cm×2.5 cm，皮瓣6 cm×4 cm。肿物距皮肤0.5 cm，切面可见部分多囊性，有血液溢出，部分实性，灰白色，鱼肉状。与周围组织界限不清。镜检院瘤组织成分复杂，有窦隙状血管瘤、海绵状血管瘤、上皮性血管内皮瘤及"血管肉瘤样"成分。免疫组化表型CD31、CD34、第Ⅷ因子、Vimentin阳性，D2-40、EMA阴性，Ki67<10%阳性。结论混合性血管内皮瘤是一种良性、低度恶性和恶性多种成分混合构成的血管肿瘤，成分多样，发生率极低。
목적：탐토혼합성혈관내피류림상병례특점、면역조화표형급이왕문헌회고복습。방법대1례전비혼합성혈관내피류병례조직병이학관찰급검험면역조화표형중적CD31、CD34、제Ⅷ인자、D2-40、EMA、Vimentin、Ki67등지표적표체。결과거검원송검종물위대사형피판조직，종물4.5 cm×3 cm×2.5 cm，피판6 cm×4 cm。종물거피부0.5 cm，절면가견부분다낭성，유혈액일출，부분실성，회백색，어육상。여주위조직계한불청。경검원류조직성분복잡，유두극상혈관류、해면상혈관류、상피성혈관내피류급"혈관육류양"성분。면역조화표형CD31、CD34、제Ⅷ인자、Vimentin양성，D2-40、EMA음성，Ki67<10%양성。결론혼합성혈관내피류시일충량성、저도악성화악성다충성분혼합구성적혈관종류，성분다양，발생솔겁저。
Objective To explore the clinicopathologic features of composite haemangioendothelioma (CHE) , its immunohistochemistry expression with review of the literature. Methods Monoclonal antibodies including CD31、CD34、Factor VIII、D2-40、EMA、Vimentin、Ki67 was used to detect the expression of this case. Results Macroscopy showed that the specimen was 4.5cmí3cmí2.5cm3 with spindle flag. Grossly,the tumor was ill-circumscribed ,with solid lesion grew white color on cut surface and cystic lesion.Microscopy showed that The tumor was composed of benign hemangioma, epithelioid hemangioendothelioma and angiosarcoma. Immunohistochemically, the tumor cells expressed only endothelial markers (CD31, CD34 and factor VIII-related antigen). Conclusion The CHE is a low frequency vascular tumor with complex morphologies of benign ,low-grade malignant and malignant vascular tumor.