CAJ | 학술논문

目的：观察低频超声治疗颈动脉斑块以及颈动脉狭窄的临床疗效。方法选择2011年4月-2013年4月在山东省聊城市人民医院脑科医院治疗的颈动脉粥样硬化患者137例，并将患者按照随机数字表法分为观察组70例和对照组67例。对照组采用常规药物治疗，观察组在对照组基础上联合应用低频超声治疗。比较两组患者治疗前后颈动脉斑块直径、形态、颈动脉狭窄程度以及血脂指标〔三酰甘油（ TG ）、血清总胆固醇（ TC ）、低密度脂蛋白胆固醇（ LDL-C）和高密度脂蛋白胆固醇（ HDL-C）〕，并记录两组患者不良反应发生情况。结果治疗前两组患者颈动脉内膜中层厚度（ IMT）、斑块直径、斑块积分比较，差异均无统计学意义（ P>0.05）；治疗后观察组IMT、斑块直径、斑块积分均低于对照组（P<0.05）。两组患者治疗后IMT、斑块直径、斑块积分均低于治疗前（P<0.05）。治疗后观察组动脉中度狭窄率和重度狭窄率均低于对照组（ P<0.05）。治疗前两组患者血脂指标比较，差异无统计学意义（ P>0.05）；治疗后观察组TC、LDL-C水平低于对照组（P<0.05）。观察组治疗后TC、LDL-C水平低于治疗前（P<0.05）。两组患者均未出现严重的不良反应。结论低频超声可以有效治疗颈动脉粥样斑块及颈动脉狭窄，为颈动脉粥样斑块的治疗开创了一种新的治疗方法，值得临床推广应用。
목적：관찰저빈초성치료경동맥반괴이급경동맥협착적림상료효。방법선택2011년4월-2013년4월재산동성료성시인민의원뇌과의원치료적경동맥죽양경화환자137례，병장환자안조수궤수자표법분위관찰조70례화대조조67례。대조조채용상규약물치료，관찰조재대조조기출상연합응용저빈초성치료。비교량조환자치료전후경동맥반괴직경、형태、경동맥협착정도이급혈지지표〔삼선감유（ TG ）、혈청총담고순（ TC ）、저밀도지단백담고순（ LDL-C）화고밀도지단백담고순（ HDL-C）〕，병기록량조환자불량반응발생정황。결과치료전량조환자경동맥내막중층후도（ IMT）、반괴직경、반괴적분비교，차이균무통계학의의（ P>0.05）；치료후관찰조IMT、반괴직경、반괴적분균저우대조조（P<0.05）。량조환자치료후IMT、반괴직경、반괴적분균저우치료전（P<0.05）。치료후관찰조동맥중도협착솔화중도협착솔균저우대조조（ P<0.05）。치료전량조환자혈지지표비교，차이무통계학의의（ P>0.05）；치료후관찰조TC、LDL-C수평저우대조조（P<0.05）。관찰조치료후TC、LDL-C수평저우치료전（P<0.05）。량조환자균미출현엄중적불량반응。결론저빈초성가이유효치료경동맥죽양반괴급경동맥협착，위경동맥죽양반괴적치료개창료일충신적치료방법，치득림상추엄응용。
Objective To observe the efficacy of low frequency ultrasound in treatment of carotid artery plaque (CAP)and carotid stenosis(CS). Methods From April 2011 to April 2013,137 atherosclerotic patients admitted to Li-aocheng Peopleˊs Hospital were divided randomly into groups study(n=70),control(n=67). Control group were given con-ventional treatment,study group combined with low frequency ultrasound. The diameter and shape of CAP,CS degree and levels of TG,TC,LDL-C,HDL-C were compared between 2 groups before and after treatment. The adverse reactions recorded. ResUlts There was no significant difference in IMT,CAP diameter,plaque scores between 2 groups before treatment( P >0. 05),lower in study group than in control group after treatment(P<0. 05),lower after treatment than before in 2 groups(P<0. 05). The moderate,severe stenosis rates were lower in study group than in control group after treatment(P <0. 05). There was no difference in lipid parameters between 2 groups before treatment(P>0. 05),the levels of TC,LDL-C lower in study group than in control group after treatment(P<0. 05). The levels of TC,LDL-C were lower after treatment than before treatment in study group( P<0. 05 ). No severe adverse reaction was noted in 2 groups. ConclUsion Low frequency ultra-sound can effectively treat CAP and CS,which has become a new treatment for CAP,worthy of clinical application.