吉林医学
吉林醫學
길림의학
JILIN MEDICAL JOURANL
2014年
23期
5091-5093
,共3页
剖宫产%重组人酸性成纤维细胞生长因子%愈合时间%瘢痕直径
剖宮產%重組人痠性成纖維細胞生長因子%愈閤時間%瘢痕直徑
부궁산%중조인산성성섬유세포생장인자%유합시간%반흔직경
Cesarean section%Recombinant human acidic fibroblast growth factor%Healing time%Scar diameter
目的：通过对再次妊娠剖宫产妇女切口愈合的应用，评价重组人酸性成纤维细胞生长因子（rhaFGF）的临床价值，并初步探寻其最佳的给药方式。方法：采用开放性临床随机对照试验设计，随机分为喷雾治疗组、冲洗治疗组和安慰剂组，喷雾组于皮肤缝合后进行rhaFGF喷雾于切口处或纱布，冲洗组于皮肤缝合前用rhaFGF清洗创面，缝合皮肤后采用喷雾组的治疗方案；安慰剂组于皮肤缝合前用生理盐水冲洗切口。术后随访观察并记录产妇切口完全愈合时间、延迟愈合人数、住院时间、临床症状，测量产妇瘢痕直径，统计患者术后切口瘙痒、后遗疼痛发生的情况。结果：与安慰剂组相比，冲洗组完全愈合时间（6.95±3.88 d与11.43±4.15 d，P=0.022），瘢痕直径（8.02±2.25 cm与11.83±3.17 cm，P=0.036）、瘙痒发生率（10.48%与42.57%，P=0.018）、后遗疼痛发生率（5.71%与20.79%，P=0.022）等方面呈现显著性差异；与喷雾组相比，冲洗组完全愈合时间（6.95±3.88 d与9.87±3.72 d， P=0.047），瘢痕直径（8.02±2.25 cm与9.41±2.96 cm，P=0.025），后遗疼痛发生率（5.71%与15.46%，P=0.047）等方面组间比较差异有统计学意义（P＜0.05）。结论：重组人酸性成纤维细胞生长因子可缩短剖宫产切口完全愈合时间，减少瘢痕直径、瘙痒和瘙痒发生率，冲洗治疗方式效果最佳。
目的：通過對再次妊娠剖宮產婦女切口愈閤的應用，評價重組人痠性成纖維細胞生長因子（rhaFGF）的臨床價值，併初步探尋其最佳的給藥方式。方法：採用開放性臨床隨機對照試驗設計，隨機分為噴霧治療組、遲洗治療組和安慰劑組，噴霧組于皮膚縫閤後進行rhaFGF噴霧于切口處或紗佈，遲洗組于皮膚縫閤前用rhaFGF清洗創麵，縫閤皮膚後採用噴霧組的治療方案；安慰劑組于皮膚縫閤前用生理鹽水遲洗切口。術後隨訪觀察併記錄產婦切口完全愈閤時間、延遲愈閤人數、住院時間、臨床癥狀，測量產婦瘢痕直徑，統計患者術後切口瘙癢、後遺疼痛髮生的情況。結果：與安慰劑組相比，遲洗組完全愈閤時間（6.95±3.88 d與11.43±4.15 d，P=0.022），瘢痕直徑（8.02±2.25 cm與11.83±3.17 cm，P=0.036）、瘙癢髮生率（10.48%與42.57%，P=0.018）、後遺疼痛髮生率（5.71%與20.79%，P=0.022）等方麵呈現顯著性差異；與噴霧組相比，遲洗組完全愈閤時間（6.95±3.88 d與9.87±3.72 d， P=0.047），瘢痕直徑（8.02±2.25 cm與9.41±2.96 cm，P=0.025），後遺疼痛髮生率（5.71%與15.46%，P=0.047）等方麵組間比較差異有統計學意義（P＜0.05）。結論：重組人痠性成纖維細胞生長因子可縮短剖宮產切口完全愈閤時間，減少瘢痕直徑、瘙癢和瘙癢髮生率，遲洗治療方式效果最佳。
목적：통과대재차임신부궁산부녀절구유합적응용，평개중조인산성성섬유세포생장인자（rhaFGF）적림상개치，병초보탐심기최가적급약방식。방법：채용개방성림상수궤대조시험설계，수궤분위분무치료조、충세치료조화안위제조，분무조우피부봉합후진행rhaFGF분무우절구처혹사포，충세조우피부봉합전용rhaFGF청세창면，봉합피부후채용분무조적치료방안；안위제조우피부봉합전용생리염수충세절구。술후수방관찰병기록산부절구완전유합시간、연지유합인수、주원시간、림상증상，측양산부반흔직경，통계환자술후절구소양、후유동통발생적정황。결과：여안위제조상비，충세조완전유합시간（6.95±3.88 d여11.43±4.15 d，P=0.022），반흔직경（8.02±2.25 cm여11.83±3.17 cm，P=0.036）、소양발생솔（10.48%여42.57%，P=0.018）、후유동통발생솔（5.71%여20.79%，P=0.022）등방면정현현저성차이；여분무조상비，충세조완전유합시간（6.95±3.88 d여9.87±3.72 d， P=0.047），반흔직경（8.02±2.25 cm여9.41±2.96 cm，P=0.025），후유동통발생솔（5.71%여15.46%，P=0.047）등방면조간비교차이유통계학의의（P＜0.05）。결론：중조인산성성섬유세포생장인자가축단부궁산절구완전유합시간，감소반흔직경、소양화소양발생솔，충세치료방식효과최가。
Objective To evaluate the clinical value of recombinant human acidic fibroblast growth factor in cesarean section for a second time pregnancy.And to study initially its best route of administration.Methods A prospective parallel randomized controlled clinical study was conducted to compare the efficacy of recombinant human acidic fibroblast growth factor in cesarean section for a second time pregnancy. These cases were randomly prospective divided into three groups,the placebo group(treated with saline washing during operation),the spray group(treated with rh-aFGF atomizing) and rinse group(treated with rh-aFGF washing during operation).The bleeding,pain,wound healing time,in-hospital days,number of delayed healing,Scar diameter and Clinical symptoms were observed every days.Results Washing rh-aFGF during operation significantly decrease the completely healing time(6.95±3.88 vs 11.43±4.15,P=0.022),scar diameter(8.02±2.25 vs 11.83±3.17,P=0.036),incidence of pruritus(10.48%vs 42.57%,P=0.018) and incidence of incisional pain(5.71%vs 20.79%,P=0.022)comparing with placebo group.Also it can significantly decrease the completely healing time(6.95±3.88 vs 9.87±3.72,P=0.047),scar diameter(8.02±2.25 vs 9.41±2.96,P=0.025) and incidence of incisional pain(5.71%vs 15.46%,P=0.047) when comparing with atomizing.Conclusion Recombinant human acidic fibroblast growth factor can not only shorted the wound healing time of cesarean,but also decrease the scar area,the incidence of pain and itching.Washing during the operation is the best route of administration.
