中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2014年
24期
35-36
,共2页
恶性综合征%临床表现%肌酶
噁性綜閤徵%臨床錶現%肌酶
악성종합정%림상표현%기매
Neuroleptic malignant syndrome%Clinical manifestation%Creatase
目的:分析恶性综合征的临床特点,以提高对本病的认识,减少误诊率。方法回顾性分析确诊的10例恶性综合征患者的临床资料,并复习相关文献。结果10例患者中,8例有抗精神病药物服用史,2例不规律服用美多芭,临床表现为发热、肌强直、肌酶增高、意识障碍及自主神经功能障碍,影像学等检查排除其他疾病,综合治疗有效。结论恶性综合征临床少见,多有抗精神病药物服药史,主要与药物影响脑内递质有关,临床表现及肌酶增高为主要的诊断依据,及时治疗大多预后良好。
目的:分析噁性綜閤徵的臨床特點,以提高對本病的認識,減少誤診率。方法迴顧性分析確診的10例噁性綜閤徵患者的臨床資料,併複習相關文獻。結果10例患者中,8例有抗精神病藥物服用史,2例不規律服用美多芭,臨床錶現為髮熱、肌彊直、肌酶增高、意識障礙及自主神經功能障礙,影像學等檢查排除其他疾病,綜閤治療有效。結論噁性綜閤徵臨床少見,多有抗精神病藥物服藥史,主要與藥物影響腦內遞質有關,臨床錶現及肌酶增高為主要的診斷依據,及時治療大多預後良好。
목적:분석악성종합정적림상특점,이제고대본병적인식,감소오진솔。방법회고성분석학진적10례악성종합정환자적림상자료,병복습상관문헌。결과10례환자중,8례유항정신병약물복용사,2례불규률복용미다파,림상표현위발열、기강직、기매증고、의식장애급자주신경공능장애,영상학등검사배제기타질병,종합치료유효。결론악성종합정림상소견,다유항정신병약물복약사,주요여약물영향뇌내체질유관,림상표현급기매증고위주요적진단의거,급시치료대다예후량호。
Objective To analyze the clinical characteristics of neuroleptic malignant syndrome (NMS) in order to improve the cognition of this disease and to reduce misdiagnosis rate.Methods The clinical data of 10 patients diagnosed with NMS were retrospectively analyzed, and the relevant literature was reviewed.Results In the 10 cases, 8 of them had long term of taking antipsychotic medication and 2 of them irregularly took the madopar tablet. Their clinical manifestations were fever, myotonia, increased muscle enzymes, disturbance of consciousness and autonomic nerve dysfunction. Other diseases were ruled out by imaging tests, and the comprehensive treatment was effective. Conclusion NMS is rare in clinic. Patients with NMS usually have a history of taking antipsychotic medication, and the drugs mainly influence the neurotransmitter in brain. Clinical manifestations and increased creatase are the main diagnostic basis for NMS. Prognosis can be good if patient is treated timely.