CAJ | 학술논문

目的：探讨光动力抗菌疗法治疗褥疮感染性伤口的疗效。方法2008年6月至2013年8月泰山医学院附属莱芜医院收治的感染性伤口褥疮患者42例。数字法随机分为光照组和对照组，每组21例，以单纯外用复方黄柏液为对照组，以复方黄柏液湿敷伤口后半导体激光照射为光照组，光照组采用复方黄柏液湿敷伤口封包30 min后半导体激光照射，半导体激光探头距离伤口部位10～15 cm，每次20 min，2次/d，连续照射7 d为1个疗程。观察两组治疗前后伤口细菌培养结果、创面炎症变化率、创面缩小率及创面肉芽组织表皮生长因子（EGF）表达。结果光照组的伤口细菌培养阳性率、治疗后第7、14天的创面周边炎症带面积变化率、创面缩小率、伤口肉芽组织EGF高表达率分别为9.8％、（32.2％±5.8％）、（89.1％±5.6％）、（12.4％±2.9％）、（34.7％±3.6％）、66.7％，对照组上述指标分别为51.2％、（17.8％±2.0％）、（57.3％±2.6％）、（5.1％±1.1％）、（10.5％±2.4％）、2/21，两组差异均有统计学意义（均P＜0.05）。结论光动力抗菌疗法治疗褥疮感染性伤口抗菌消炎效果明显，通过高表达EGF促进伤口愈合。
목적：탐토광동력항균요법치료욕창감염성상구적료효。방법2008년6월지2013년8월태산의학원부속래무의원수치적감염성상구욕창환자42례。수자법수궤분위광조조화대조조，매조21례，이단순외용복방황백액위대조조，이복방황백액습부상구후반도체격광조사위광조조，광조조채용복방황백액습부상구봉포30 min후반도체격광조사，반도체격광탐두거리상구부위10～15 cm，매차20 min，2차/d，련속조사7 d위1개료정。관찰량조치료전후상구세균배양결과、창면염증변화솔、창면축소솔급창면육아조직표피생장인자（EGF）표체。결과광조조적상구세균배양양성솔、치료후제7、14천적창면주변염증대면적변화솔、창면축소솔、상구육아조직EGF고표체솔분별위9.8％、（32.2％±5.8％）、（89.1％±5.6％）、（12.4％±2.9％）、（34.7％±3.6％）、66.7％，대조조상술지표분별위51.2％、（17.8％±2.0％）、（57.3％±2.6％）、（5.1％±1.1％）、（10.5％±2.4％）、2/21，량조차이균유통계학의의（균P＜0.05）。결론광동력항균요법치료욕창감염성상구항균소염효과명현，통과고표체EGF촉진상구유합。
Objective To explore the efficacy of photodynamic antimicrobial therapy in the treatment of pressure sore with pathogen infection.Methods A total of 42 pressure sore patients with pathogen infection were divided randomly into experimental and control groups ( n =21 each ) .Fufanghuangbai liquid was used for external application with control group.In the experimental group , wound was treated with Fufanghuangbai liquid wet dressing and irradiated by semiconductor laser 30 min late.The distance from semiconductor laser probe to wound site was 10 -15 cm, 20 min twice daily , continuous exposure to 7 days for 1 course.The results of bacterial culture and epidermal growth factor ( EGF) expression of wound granulation tissue were observed before and after treatment.And the changes of healing rate of pressure sore were measured at post-treatment in each group.Results The positive rates of bacterial culture, rates of change around wound inflammation , healing rate of days 7 and 14, the high expression of EGF on healing wound granulation tissue was 9.75%, ( 32.2% ±5.8%) , ( 89.1% ± 5.6%), ( 12.4% ±2.9%), ( 34.7% ±3.6%), 14/21 in the treatment group versus 51.2%, (17.8%±2.0%), (57.3%±2.6%), (5.1%±1.1%), (10.5%±2.4%), 2/21 in the control group respectively.The inter-group differences were statistically significant ( P <0.05 ) .Conclusion Photodynamic antimicrobial therapy is an effective method for pressure sore with pathogen infection.Wound healing is promoted through an up-regulation of EGF.