CAJ | 학술논문

目的：调查研究不同高原移居人群返回平原后血生化指标的变化。 　　方法：于2012年3至12月选择移居海拔3700-5380 m 半年以上的男性青年124名返回平原（1400 m）后4 d，分别按年龄、移居高原时间和是否持续移居高原分组比较血生化指标。检测项目包括门冬氨酸氨基转移酶（AST）、谷丙转氨酶(ALT)、γ-谷氨酰转移酶（γ-GT）、碱性磷酸酶（ALP）、肌酐(CR)、尿素氮(UN)、尿酸(UA)、总蛋白（TP）、白蛋白(ALB)、总胆红素（STB）、直接胆红素（SDB）等。 　　结果：纳入汉族男性青年124名，均进入结果分析。与28岁以下组比较，28岁以上组ALT、ALP、STB增高，AST、ALT、UA异常率增高(P<0.05)，与4年以下组比较，4年以上组UA、STB增高，AST异常率增高(P<0.05，或P<0.01)，间断组较连续组ALT异常率增高(P<0.05)。 　　结论：高原脱适应者血生化指标指标多项异常，肝脏损害最大，随着年龄增大和高原暴露时间增加指标异常增多，间断高原暴露损害更明显。
목적：조사연구불동고원이거인군반회평원후혈생화지표적변화。 　　방법：우2012년3지12월선택이거해발3700-5380 m 반년이상적남성청년124명반회평원（1400 m）후4 d，분별안년령、이거고원시간화시부지속이거고원분조비교혈생화지표。검측항목포괄문동안산안기전이매（AST）、곡병전안매(ALT)、γ-곡안선전이매（γ-GT）、감성린산매（ALP）、기항(CR)、뇨소담(UN)、뇨산(UA)、총단백（TP）、백단백(ALB)、총담홍소（STB）、직접담홍소（SDB）등。 　　결과：납입한족남성청년124명，균진입결과분석。여28세이하조비교，28세이상조ALT、ALP、STB증고，AST、ALT、UA이상솔증고(P<0.05)，여4년이하조비교，4년이상조UA、STB증고，AST이상솔증고(P<0.05，혹P<0.01)，간단조교련속조ALT이상솔증고(P<0.05)。 　　결론：고원탈괄응자혈생화지표지표다항이상，간장손해최대，수착년령증대화고원폭로시간증가지표이상증다，간단고원폭로손해경명현。
To investigate the Changes of some blood biochemical indexes in de-adaptation of people back to low altitude (1 400 m)after exposure to high altitude(from 3 700 m to 5 380 m). From March 2012 to December 2012, 124 male youths who stay at high altitude for more than half year were grouped by age, total times stayed at high altitude and continued exposure or not. Aspartate aminotransferase (AST), alanine aminotransferase (ALT),γ-glutamyl transferase (γ-GT), alkaline phosphatase (ALP), creatinine (Cr), blood urea nitrogen (UN), uric acid (UA), total protein (TP), albumin (ALB), serum total bilirubin (STB) and serum direct bilirubin (SDB) were detected after 4 days they back to low altitude. Al the 124 youths were involved in the result analysis. Compared with below 28-year-old group, ALT, ALP STB and abnormal rate of AST, ALT, UA in group above 28-year-old increased(P<0.05). Compared with below 4 years group, UA, STB and abnormal rate of AST in group above 4 years increased(P<0.05, or P<0.01). Compared with continued group, abnormal rate of ALT in non-continued group increased(P<0.05). The multinomial indexes of blood biochemical are abnormal in de-adaptation of people back to low altitude. The damages to liver are most seriously and the Severity of damages relate to the age and time exposure to high altitude.