CAJ | 학술논문

目的探讨血清抗Sm抗体与儿童系统性红斑狼疮(SLE)临床表现和疾病活动度之间的相关性.方法根据SLE疾病活动指数(SLEDAI)评分将72例SLE患儿分成无活动组和活动组,用免疫印迹法检测患儿的血清抗Sm抗体,分析抗Sm抗体与SLE临床表现和疾病活动度之间的关系.结果 72例SLE患儿中无活动组28例(38.9％),活动组44例(61.1％).血清抗Sm抗体阳性17例(23.6％),阴性55例(76.4％).抗Sm抗体阳性者肾损害的发生率(70.6％,12/17)高于抗Sm抗体阴性者(41.8％,23/55),差异有统计学意义(P＜0.05).活动组抗Sm抗体阳性14例(31.8％,14/44),无活动组抗Sm抗体阳性3例(10.7％,3/28),两组比较差异有统计学意义(P＜0.05).结论血清抗Sm抗体不仅是SLE患儿临床诊断的重要指标,同时也是SLE病情活动及肾脏损害的危险因素.
목적 탐토혈청항Sm항체여인동계통성홍반랑창(SLE)림상표현화질병활동도지간적상관성.방법 근거SLE질병활동지수(SLEDAI)평분장72례SLE환인분성무활동조화활동조,용면역인적법검측환인적혈청항Sm항체,분석항Sm항체여SLE림상표현화질병활동도지간적관계.결과 72례SLE환인중무활동조28례(38.9％),활동조44례(61.1％).혈청항Sm항체양성17례(23.6％),음성55례(76.4％).항Sm항체양성자신손해적발생솔(70.6％,12/17)고우항Sm항체음성자(41.8％,23/55),차이유통계학의의(P＜0.05).활동조항Sm항체양성14례(31.8％,14/44),무활동조항Sm항체양성3례(10.7％,3/28),량조비교차이유통계학의의(P＜0.05).결론 혈청항Sm항체불부시SLE환인림상진단적중요지표,동시야시SLE병정활동급신장손해적위험인소.
Objective To assess the associations of anti-Smith antibodies with clinical manifestations and disease activity in children with systemic lupus erythematosus (SLE).Methods According to SLE disease activity index (SLEDAI) score,72 children with SLE were divided into the active group and inactive group.An immunoblotting method was used to detect serum anti-Smith antibodies in these subjects.Chi-square test was conducted to assess the associations of anti-Smith antibodies with clinical manifestations and disease activity in these patients.Results Of these patients,28 (38.9％) were assigned into the inactive group,and 44 (61.1％) to the active group.Anti-Smith antibodies were detected in 17 (23.6％) patients,but not in the other 55 (76.4％) patients.Elevated incidence rate of kidney injury was observed in anti-Smith antibody-positive patients compared with anti-Smith antibody-negative patients (70.6％ (12/17) vs.41.8％ (23/55),P ＜ 0.05).Meanwhile,the positivity rate of anti-Smith antibodies was 31.8％ (14/44) in the active group,significantly higher than that in the inactive group (10.7％,3/28,P ＜ 0.05).Conclusions Anti-Smith antibodies are not only an important indicator for the diagnosis of SLE,but also a risk factor for disease exacerbation and kidney injury in children with SLE.