CAJ | 학술논문

目的探讨唑来膦酸联合化疗治疗晚期非小细胞肺癌骨转移的临床效果.方法选取我院于2011年7月至2013年7月收治的42例晚期非小细胞肺癌骨转移患者作为研究对象,按照随机分组方式将患者分为观察组21例和对照组21例,对照组给予常规化疗措施,观察组在化疗基础上给予唑来膦酸治疗,对两组患者NRS、KPS水平进行测评,评价两种治疗方式的效果.结果观察组骨转移灶完全缓解7例,部分缓解9例,稳定4例,恶化1例,综合有效率(完全缓解+部分缓解)为76.19％,对照组完全缓解4例,部分缓解3例,稳定5例,恶化9例,综合有效率为33.33％,两组患者综合有效率对比具有显著的统计学差异(P＜0.01);两组患者经治疗后NRS、KPS均有不同程度改善,相比治疗前差异有统计学意义(P＜0.05),观察组改善更为明显,相比对照组差异有统计学意义(P＜0.05).结论唑来膦酸联合化疗治疗晚期非小细胞肺癌骨转移疗效显著,对于缓解患者疼痛、改善患者预后具有重要的临床意义.
목적 탐토서래련산연합화료치료만기비소세포폐암골전이적림상효과.방법 선취아원우2011년7월지2013년7월수치적42례만기비소세포폐암골전이환자작위연구대상,안조수궤분조방식장환자분위관찰조21례화대조조21례,대조조급여상규화료조시,관찰조재화료기출상급여서래련산치료,대량조환자NRS、KPS수평진행측평,평개량충치료방식적효과.결과 관찰조골전이조완전완해7례,부분완해9례,은정4례,악화1례,종합유효솔(완전완해+부분완해)위76.19％,대조조완전완해4례,부분완해3례,은정5례,악화9례,종합유효솔위33.33％,량조환자종합유효솔대비구유현저적통계학차이(P＜0.01);량조환자경치료후NRS、KPS균유불동정도개선,상비치료전차이유통계학의의(P＜0.05),관찰조개선경위명현,상비대조조차이유통계학의의(P＜0.05).결론 서래련산연합화료치료만기비소세포폐암골전이료효현저,대우완해환자동통、개선환자예후구유중요적림상의의.
Objective To explore the clinical effects of zoledronic acid combined with chemotherapy in patients with advanced non-small cell lung cancer with bone metastases.Methods In our hospital from July 2011 to July 2013 42 cases of advanced lung cancer patients with bone metastases in non-small cell were selected for the study,and they were randomly divided into observation group (21 cases) and control group (21 cases),the control group received conventional chemotherapy measures,observation group was given zoledronic acid treatment on the basis of chemotherapy,NRS,KPS levels in both groups were detected and evaluated,and the curative effects of two treatment methods were compared.Results In observation group of bone metastases,there were 7 cases of complete remission,partial remission in 9 cases,4 cases of stable,worsening 1 case,a comprehensive response rate (complete response + partial response) was 76.19％;in the control group there were 4 cases of complete remission,partial remission in 3 cases,stable 5 cases,the deterioration of 9 cases,consolidated effective rate of 33.33％,comparing the two groups of patients with comprehensive efficiency statistically significant difference (P ＜ 0.01); after treatment the NRS,KPS levels were improved,showing statistical significant difference compared to those before treatment(P ＜ 0.05),observation group improved more significantly than the control group,showing statistical significant difference (P ＜ 0.05).Conclusion Zoledronic acid combined with chemotherapy in the treatment of advanced lung cancer bone metastasis in patients with non-small cell significantly alleviating pain in patients,can improve the prognosis of patients with important clinical significance.