CAJ | 학술논문

目的：探究肺癌患者急性放射性肺损伤发生的相关影响因素。方法将我院2009年至2012年收治的200例行放射治疗的肺癌病患作为研究对象，对他们的性别、年龄、是否化疗、放疗的剂量、V5、V20及平均剂量（MLD）等因素和病患三级及以上急性放射性肺损伤发生率之间的关系进行分析。结果本研究200例放射治疗的肺癌病患，发生三级及以上急性放射性肺损伤的病患为93例（46.50%），对相关因素进行分析后发现以下因素可导致病患发生三级及以上急性放射性肺损伤：吸烟、放疗前化疗周期数较多、同期放化疗、V5>40%、V20>25%（28%）、MLD>10Gy（13Gy）。结论在进行肺癌放疗计划设计时，应根据我国肺癌病患的特点，设定适宜的物理参数；还应对病患的吸烟史、化疗史等因素进行分析，尽量减少急性放射性肺损伤的发生率。
목적：탐구폐암환자급성방사성폐손상발생적상관영향인소。방법장아원2009년지2012년수치적200례행방사치료적폐암병환작위연구대상，대타문적성별、년령、시부화료、방료적제량、V5、V20급평균제량（MLD）등인소화병환삼급급이상급성방사성폐손상발생솔지간적관계진행분석。결과본연구200례방사치료적폐암병환，발생삼급급이상급성방사성폐손상적병환위93례（46.50%），대상관인소진행분석후발현이하인소가도치병환발생삼급급이상급성방사성폐손상：흡연、방료전화료주기수교다、동기방화료、V5>40%、V20>25%（28%）、MLD>10Gy（13Gy）。결론재진행폐암방료계화설계시，응근거아국폐암병환적특점，설정괄의적물리삼수；환응대병환적흡연사、화료사등인소진행분석，진량감소급성방사성폐손상적발생솔。
Objective?To explore the influence factors related to the occurrence of acute radiation lung injury in patients with lung cancer. Methods Our hospital in the years 2009 to 2012 in 200 consecutive patients who underwent radiotherapy for lung cancer patients as the research object, to their gender, age, chemotherapy, radiotherapy dose, V5, V20 and mean dose (MLD) and the factors such as patient three or more acute radiation lung injury incidence and relation between analysis. Results In this study, 200 cases of radiation therapy for lung cancer patients, grade three and above acute radiation lung injury patients for 93 cases (46.50%), to analyze the related factors and found the fol owing factors can cause disease incidence of grade three and above acute radiation lung injury:smoking, radiotherapy before the chemotherapy cycle number, chemotherapy, V5>40%, V20>25%(28%), MLD>10Gy (13Gy). Conclusion The lung cancer radiotherapy plan, should according to the characteristics of Chinese lung cancer patients, set ing parameters suitable;factors to smoking history, disease history of chemotherapy, to reduce the incidence of acute radiation lung injury.