重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2013年
29期
3500-3502
,共3页
冠心病%冠状动脉%造影%脂蛋白类, HDL%酯化
冠心病%冠狀動脈%造影%脂蛋白類, HDL%酯化
관심병%관상동맥%조영%지단백류, HDL%지화
coronary heart disease%coronary artery%angiography%lipoproteins,HDL%esterification
目的:探讨分析高密度脂蛋白胆固醇酯化速率(FERHDL )与冠心病的关系及其具体应用价值。方法回顾性分析该院近3年进行冠状动脉造影的患者,依据冠状动脉造影的结果将286例患者分为冠心病组(n=196)与非冠心病组(对照组,n=90),冠心病组根据狭窄病变累及血管范围分为1支病变(单支病变组,n=73例)、2支病变(双支病变组,n=72)和3支及以上病变(多支病变组,n=51),分析FERHDL与冠心病的具体关系及相关性。结果冠心病组 FERHDL 明显高于对照组,差异具有统计学意义(P<0.05)。FERHDL随冠状动脉病变范围的增加而升高即在单支病变、双支病变、三支病变组间有升高趋势,组间比较差异有统计学意义(P<0.05)。FERHDL与低密度脂蛋白胆固醇b-C(LDLb-C)、三酰甘油(TG)、高密度脂蛋白胆固醇2C (HDL2-C)、高密度脂蛋白胆固醇C(HDL-C)存在显著的独立相关关系,即与LDLb-C(r=8.473,P=0.000)、TG(r=0.714,P=0.002)呈正相关,与 HDL2-C(r=-0.692,P=0.024)、HDL-C(r=-0.829,P=0.008)呈负相关。结论 FERHDL随冠心病患者病情加重而增高。FERHDL的变化与 HDL和LDL颗粒直径大小密切相关。
目的:探討分析高密度脂蛋白膽固醇酯化速率(FERHDL )與冠心病的關繫及其具體應用價值。方法迴顧性分析該院近3年進行冠狀動脈造影的患者,依據冠狀動脈造影的結果將286例患者分為冠心病組(n=196)與非冠心病組(對照組,n=90),冠心病組根據狹窄病變纍及血管範圍分為1支病變(單支病變組,n=73例)、2支病變(雙支病變組,n=72)和3支及以上病變(多支病變組,n=51),分析FERHDL與冠心病的具體關繫及相關性。結果冠心病組 FERHDL 明顯高于對照組,差異具有統計學意義(P<0.05)。FERHDL隨冠狀動脈病變範圍的增加而升高即在單支病變、雙支病變、三支病變組間有升高趨勢,組間比較差異有統計學意義(P<0.05)。FERHDL與低密度脂蛋白膽固醇b-C(LDLb-C)、三酰甘油(TG)、高密度脂蛋白膽固醇2C (HDL2-C)、高密度脂蛋白膽固醇C(HDL-C)存在顯著的獨立相關關繫,即與LDLb-C(r=8.473,P=0.000)、TG(r=0.714,P=0.002)呈正相關,與 HDL2-C(r=-0.692,P=0.024)、HDL-C(r=-0.829,P=0.008)呈負相關。結論 FERHDL隨冠心病患者病情加重而增高。FERHDL的變化與 HDL和LDL顆粒直徑大小密切相關。
목적:탐토분석고밀도지단백담고순지화속솔(FERHDL )여관심병적관계급기구체응용개치。방법회고성분석해원근3년진행관상동맥조영적환자,의거관상동맥조영적결과장286례환자분위관심병조(n=196)여비관심병조(대조조,n=90),관심병조근거협착병변루급혈관범위분위1지병변(단지병변조,n=73례)、2지병변(쌍지병변조,n=72)화3지급이상병변(다지병변조,n=51),분석FERHDL여관심병적구체관계급상관성。결과관심병조 FERHDL 명현고우대조조,차이구유통계학의의(P<0.05)。FERHDL수관상동맥병변범위적증가이승고즉재단지병변、쌍지병변、삼지병변조간유승고추세,조간비교차이유통계학의의(P<0.05)。FERHDL여저밀도지단백담고순b-C(LDLb-C)、삼선감유(TG)、고밀도지단백담고순2C (HDL2-C)、고밀도지단백담고순C(HDL-C)존재현저적독립상관관계,즉여LDLb-C(r=8.473,P=0.000)、TG(r=0.714,P=0.002)정정상관,여 HDL2-C(r=-0.692,P=0.024)、HDL-C(r=-0.829,P=0.008)정부상관。결론 FERHDL수관심병환자병정가중이증고。FERHDL적변화여 HDL화LDL과립직경대소밀절상관。
Objective To assess the relationship between fractional esterification rate of high density lipoprotein cholesterol (FERHDL) and coronary artery disease .Methods The patients were underwent coronary angiography in this hospital in the last three years were collected ,according to the results of coronary angiography ,286 patients were divided into CHD group(n=196) and non-CHD group(control group ,n=90) .And according to the number of pathological coronary artery ,the patients with coronary heart disease were divided into single-vessel subgroup(n=73) ,double vessel lesion subgroup(n=72) ,three branch lesions subgroup (n=51) .The relationship between FERHDL and coronary artery disease were analyzed .Results The FERHDL of CHD group was significantly higher than that in the control group ,the difference was statistically significant (P<0 .05) .It was a tendency that the FERHDL increased with coronary lesions increasing (P<0 .05) .The FERHDL was significant independent correlated with the low density lipoprotein cholesterol b-C(LDLb-C) ,triglycerides(TG) ,high density lipoprotein cholesterol 2-C(HDL2-C) ,high density lipoprotein cholesterol C(HDL-C) .FERHDL was positively correlated with LDLb-C(r=8 .473 ,P=0 .000) ,TG(r=0 .714 ,P=0 .002) and negatively correlated with HDL2-C(r= -0 .692 ,P=0 .024)、HDL-C(r= -0 .829 ,P=0 .008) .Conclusion The value of FERHDL was significantly increased in CHD patients and correlated with the aggravation severity of the CHD .The change of FERHDL was significant correlated with particle size of HDL and LDL particle size .